ArticleBMC complementary and alternative medicine2012
Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats.
Article in BMC complementary and alternative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Hypoglycemic and tissue protective effects of mangosteen (Garcinia mangostana L.) on diabetes associated periodontal tissue alterations.Odontology · 2026Article
- The Conventional and Alternative Therapeutic Approaches in Arterial Stiffness Management.Pharmaceutics · 2026Review
- Various parts ofFrontiers in molecular biosciences · 2026Review
- Carica papaya in health and disease: a review of its bioactive compounds for treating various disease conditions, including anti-inflammatory and anti-arthritic activities.Inflammopharmacology · 2025Review
- Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review.Nutrients · 2024Review
- Valorization of pawpaw (Food chemistry: X · 2024Article
- Supplementation of papaya leaf juice has beneficial effects on glucose homeostasis in high fat/high sugar-induced obese and prediabetic adult mice.BMC complementary medicine and therapies · 2024Article
- Analysis of Antidiabetic Activity of Squalene via In Silico and In Vivo Assay.Molecules (Basel, Switzerland) · 2023Article
- Characterization of Green and Yellow Papaya (Nutrients · 2023Article
- Uses of Papaya Leaf and Seaweed Supplementations for Controlling Glucose Homeostasis in Diabetes.International journal of molecular sciences · 2023Review
- Antidiabetic Potential of Commonly Available Fruit Plants in Bangladesh: Updates on Prospective Phytochemicals and Their Reported MoAs.Molecules (Basel, Switzerland) · 2022Review
- Review
- Possible Synergistic Antidiabetic Effects of QuantifiedBiology · 2021Article
- Putative abrogation impacts of Ajwa seeds on oxidative damage, liver dysfunction and associated complications in rats exposed to carbon tetrachloride.Molecular biology reports · 2021Article
- Beneficial Role ofBiology · 2021Review
- Evaluation of the Hypoglycemic Activity ofFrontiers in pharmacology · 2021Article
- Therapeutic application of Carica papaya leaf extract in the management of human diseases.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Review
- Therapeutic Efficacy ofBiomolecules · 2020Article
- Antidiabetic Effect of GerminatedJournal of experimental pharmacology · 2020Article
- Nutraceutical Potential ofNutrients · 2019Review
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTraditional plant treatment for diabetes has shown a surging interest in the last few decades. Therefore, the purpose of this study was to assess the hypoglycemic effect of the aqueous extract of C. papaya leaves in diabetic rats. Several studies have reported that some parts of the C. papaya plant exert hypoglycemic effects in both animals and humans.
methodsDiabetes was induced in rats by intraperitoneal administration of 60 mg/kg of streptozotocin (STZ). The aqueous extract of C. papaya was administered in three different doses (0.75, 1.5 and 3 g/100 mL) as drinking water to both diabetic and non-diabetic animals during 4 weeks.
resultsThe aqueous extract of Carica papaya (0.75 g and 1.5 g/100 mL) significantly decreased blood glucose levels (p<0.05) in diabetic rats. It also decreased cholesterol, triacylglycerol and amino-transferases blood levels. Low plasma insulin levels did not change after treatment in diabetic rats, but they significantly increased in non-diabetic animals. Pancreatic islet cells were normal in non-diabetic treated animals, whereas in diabetic treated rats, C. papaya could help islet regeneration manifested as preservation of cell size. In the liver of diabetic treated rats, C. papaya prevented hepatocyte disruption, as well as accumulation of glycogen and lipids. Finally, an antioxidant effect of C. papaya extract was also detected in diabetic rats.
conclusionsThis study showed that the aqueous extract of C. papaya exerted a hypoglycemic and antioxidant effect; it also improved the lipid profile in diabetic rats. In addition, the leaf extract positively affected integrity and function of both liver and pancreas.
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