ArticleJournal of neurotrauma2013
Laser therapy and pain-related behavior after injury of the inferior alveolar nerve: possible involvement of neurotrophins.
Article in Journal of neurotrauma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Photobiomodulation treatment in incomplete spinal cord injuries or peripheral nerve injuries: a comprehensive systematic review of randomized clinical trials.Lasers in medical science · 2025Pooled it
- The effectiveness of photobiomodulation therapy on inferior alveolar nerve injury: A systematic review and META-analysis.PloS one · 2023Pooled it
- The effect of low-level laser radiation on improving inferior alveolar nerve damage after sagittal split osteotomy: a systematic review.Lasers in medical science · 2019Pooled it
- Photobiomodulation for the management of inferior alveolar nerve paresthesia after implant surgery: A randomized clinical trial.Medicina oral, patologia oral y cirugia bucal · 2026Trial
- Effects of Photobiomodulation on Ventilatory Mechanics and Inflammatory Response in a Rat Model of Acute Lung Injury.Journal of lasers in medical sciences · 2026Article
- Investigation of the effect of photobiomodulation therapy with different wavelengths on nerve regeneration: an experimental study.BMC oral health · 2025Article
- Photobiomodulation Therapy for Neurosensory Disturbances in Orthognathic Surgery Patients: A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Efficacy of Blood Products and Photobiomodulation Therapy for Neurosensory Recovery in Patients With Inferior Alveolar Nerve Injury Following Orthognathic Surgery: A Systematic Review Study.Journal of lasers in medical sciences · 2025Review
- Prevention and reversal of neuropathic pain by near-infrared photobiomodulation therapy in male and female rats.Physiology & behavior · 2024Article
- The Comparison of 940nm and 810nm Diode Laser Effects on the Repair of Inferior Alveolar Sensory Nerve Injury: A Clinical Trial.Journal of dentistry (Shiraz, Iran) · 2024Article
- Unraveling the RAGE-NF-κB pathway: implications for modulating inflammation in diabetic neuropathy through photobiomodulation therapy.Lasers in medical science · 2024Article
- Enhancing nerve regeneration in infraorbital nerve injury rat model: effects of vitamin B complex and photobiomodulation.Lasers in medical science · 2024Article
- Photobiomodulation and vitamin B treatment alleviate both thermal and mechanical orofacial pain in rats.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Effects of Low-Level Laser Therapy and Purified Natural Latex (International journal of molecular sciences · 2023Article
- Efficacy of LED Photobiomodulation for Functional and Axonal Regeneration After Facial Nerve Section-Suture.Frontiers in neurology · 2022Article
- Effects of photobiomodulation therapy on neuropathic pain in rats: evaluation of nociceptive mediators and infrared thermography.Lasers in medical science · 2021Article
- Mitochondrial Bioenergetic, Photobiomodulation and Trigeminal Branches Nerve Damage, What's the Connection? A Review.International journal of molecular sciences · 2021Review
- Comparative effects of photobiomodulation therapy at wavelengths of 660 and 808 nm on regeneration of inferior alveolar nerve in rats following crush injury.Lasers in medical science · 2020Article
- The effectiveness of photobiomodulation in the management of temporomandibular pain sensitivity in rats: behavioral and neurochemical effects.Lasers in medical science · 2020Article
- Photobiomodulation and B vitamins administration produces antinociception in an orofacial pain model through the modulation of glial cells and cytokines expression.Brain, behavior, & immunity - health · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve-related complications have been frequently reported in dental procedures, and a very frequent type of occurrence involves the inferior alveolar nerve (IAN). The nerve injury in humans often results in persistent pain accompanied by allodynia and hyperalgesia. In this investigation, we used an experimental IAN injury in rats, which was induced by a Crile hemostatic clamp, to evaluate the effects of laser therapy on nerve repair. We also studied the nociceptive behavior (von Frey hair test) before and after the injury and the behavioral effects of treatment with laser therapy (emitting a wavelength of 904 nm, output power of 70 Wpk, a spot area of ∼0.1 cm², frequency of 9500 Hz, pulse time 60 ns and an energy density of 6 J/cm²). As neurotrophins are essential for the process of nerve regeneration, we used immunoblotting techniques to preliminarily examine the effects of laser therapy on the expression of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). The injured animals treated with laser exhibited an improved nociceptive behavior. In irradiated animals, there was an enhanced expression of NGF (53%) and a decreased BDNF expression (40%) after laser therapy. These results indicate that BDNF plays a locally crucial role in pain-related behavior development after IAN injury, increasing after lesions (in parallel to the installation of pain behavior) and decreasing with laser therapy (in parallel to the improvement of pain behavior). On the other hand, NGF probably contributes to the repair of nerve tissue, in addition to improving the pain-related behavior.
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