ReviewAnnual review of medicine2013
Treating the developing brain: implications from human imaging and mouse genetics.
Review in Annual review of medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Neural Substrates of Emotion Processing and Cognitive Control Over Emotion in Youth Anxiety: An RDoC-Informed Study Across the Clinical to Nonclinical Continuum of Severity.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Trial
- The stoned age: Sex differences in the effects of adolescent cannabinoid exposure on prefrontal cortex structure and function in animal models.International review of neurobiology · 2022Review
- Individual-specific functional connectivity of the amygdala: A substrate for precision psychiatry.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Grant Report on Anxiety-CBT: Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety.Journal of psychiatry and brain science · 2020Article
- Adolescent ΔBiological psychiatry · 2019Article
- Stress and the adolescent brain: Amygdala-prefrontal cortex circuitry and ventral striatum as developmental targets.Neuroscience and biobehavioral reviews · 2016Review
- The Role of BDNF in the Development of Fear Learning.Depression and anxiety · 2016Review
- The typical development of posterior medial frontal cortex function and connectivity during task control demands in youth 8-19years old.NeuroImage · 2016Article
- Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.The Journal of biological chemistry · 2016Article
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Error-processing abnormalities in pediatric anxiety and obsessive compulsive disorders.CNS spectrums · 2015Review
- Spatiotemporal dynamics of the postnatal developing primate brain transcriptome.Human molecular genetics · 2015Article
- Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies.Neuron · 2015Review
- Sensitive periods in affective development: nonlinear maturation of fear learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Risk for anxiety and implications for treatment: developmental, environmental, and genetic factors governing fear regulation.Annals of the New York Academy of Sciences · 2013Article
- Fear learning and memory across adolescent development: Hormones and Behavior Special Issue: Puberty and Adolescence.Hormones and behavior · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
A fundamental issue in psychiatric medicine is the lack of empirical evidence indicating when, during development, a treatment will be most effective for a patient. We review behavioral and brain changes that occur across development, focusing on the period of adolescence, when there is a peak in diagnosis of many psychiatric disorders. We use anxiety disorders as an example because of their high prevalence in youth (affecting as many as 1 in 10). Basic forms of fear learning, which are at the core of anxiety disorders and are the targets of behavioral therapeutics, are examined as a function of age. We also discuss how fear learning has been genetically modulated in mice and humans. Based on these findings, we provide future directions for determining the efficacy of innovative therapies and preventive strategies for anxiety disorders as a function of age and potential genetic effects inferred from mice and humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.