ArticleTissue engineering. Part C, Methods2013
Evaluation of angiogenesis of bioactive glass in the arteriovenous loop model.
Article in Tissue engineering. Part C, Methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04001842 (Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes
Who cites it
20 citing papers in PubMed, 85 citations in OpenAlex.
- Bioactive glass BAG-S53P4 for the adjunctive treatment of chronic osteomyelitis of the long bones: an in vitro and prospective clinical study.BMC infectious diseases · 2013Trial
- NovaBone Bioactive Glass for Oral Bone Regeneration: Mechanisms, Innovations, and Clinical Outcomes.Cureus · 2026Review
- Biofabrication of 3D-printed, pre-cross-linked alginate dialdehyde-gelatin (ADA-GEL) scaffolds for anFrontiers in bioengineering and biotechnology · 2025Article
- Antibacterial, pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing.Bioactive materials · 2021Article
- Combining Vascularization Strategies in Tissue Engineering: The Faster Road to Success?Frontiers in bioengineering and biotechnology · 2020Article
- Oral Bone Tissue Engineering: Advanced Biomaterials for Cell Adhesion, Proliferation and Differentiation.Materials (Basel, Switzerland) · 2019Review
- Cellular Based Strategies for Microvascular Engineering.Stem cell reviews and reports · 2019Review
- Soy Protein-Based Composite Hydrogels: Physico-Chemical Characterization and In Vitro Cytocompatibility.Polymers · 2018Article
- Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells in Alginate Dialdehyde/Gelatin Microbeads with and without Nanoscaled Bioactive Glass for In Vivo Bone Tissue Engineering.Materials (Basel, Switzerland) · 2018Article
- The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering.Journal of visualized experiments : JoVE · 2016Article
- Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo.Journal of materials science. Materials in medicine · 2016Article
- Angiogenic potential of extracellular matrix of human amniotic membrane.Tissue engineering and regenerative medicine · 2016Review
- Vessel transformation in chronic wounds under topical negative pressure therapy: an immunohistochemical analysis.International wound journal · 2015Article
- Flow increase is decisive to initiate angiogenesis in veins exposed to altered hemodynamics.PloS one · 2015Article
- Enhancing mandibular bone regeneration and perfusion via axial vascularization of scaffolds.Clinical oral investigations · 2014Article
- Successful human long-term application of in situ bone tissue engineering.Journal of cellular and molecular medicine · 2014Article
- Article
- Bioactive copper-doped glass scaffolds can stimulate endothelial cells in co-culture in combination with mesenchymal stem cells.PloS one · 2014Article
- Estimating the 3D pore size distribution of biopolymer networks from directionally biased data.Biophysical journal · 2013Article
- Strategies and First Advances in the Development of Prevascularized Bone Implants.Current molecular biology reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the angiogenetic effect of sintered 45S5 Bioglass® was quantitatively assessed for the first time in the arteriovenous loop (AVL) model. An AVL was created by interposition of a venous graft from the contralateral side between the femoral artery and vein in the medial thigh of eight rats. The loop was placed in a Teflon isolation chamber and was embedded in a sintered 45S5 Bioglass® granula matrix filled with fibrin gel. Specimens were investigated 3 weeks postoperatively by means of microcomputed tomography, histological, and morphometrical techniques. All animals tolerated the operations well. At 3 weeks, both microcomputed tomography and histology demonstrated a dense network of newly formed vessels originating from the AVL. All constructs were filled with cell-rich, highly vascularized connective tissue around the vascular axis. Analysis of vessel diameter revealed constant small vessel diameters, indicating immature new vessel sprouts. This study shows for the first time axial vascularization of a sintered 45S5 Bioglass® granula matrix. After 3 weeks, the newly generated vascular network already interfused most parts of the scaffolds and showed signs of immaturity. The intrinsic type of vascularization allows transplantation of the entire construct using the AVL pedicle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.