ArticleThe Journal of clinical investigation1990
Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease.
Article in The Journal of clinical investigation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 87 citations in OpenAlex.
- Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Trial
- Role of the Endocannabinoid/Endovanilloid System in the Modulation of Osteoclast Activity in Paget's Disease of Bone.International journal of molecular sciences · 2021Article
- Article
- Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.Cell death and differentiation · 2020Article
- Epidemiology and pathology of Paget's disease of bone - a review.Wiener medizinische Wochenschrift (1946) · 2017Review
- Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease.The Journal of clinical investigation · 2016Article
- Article
- Genotype-phenotype correlation in juvenile Paget disease: role of molecular alterations of the TNFRSF11B gene.Endocrine · 2012Review
- Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.Cell metabolism · 2011Article
- Emerging strategies and therapies for treatment of Paget's disease of bone.Drug design, development and therapy · 2011Review
- The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.Molecular endocrinology (Baltimore, Md.) · 2009Article
- A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment.Human molecular genetics · 2008Article
- 1alpha,25-Dihydroxyvitamin D(3)-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells.The Journal of steroid biochemistry and molecular biology · 2008Article
- Use of zoledronic acid in the treatment of Paget's disease.Therapeutics and clinical risk management · 2007Article
- Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease.The Journal of clinical investigation · 2007Article
- Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone.The Journal of clinical investigation · 2000Article
- Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype.The Journal of clinical investigation · 2000Article
- The role of 1,25-dihydroxycholecalciferol and prostaglandin E2 in the regulation of human osteoclastic bone resorption in vitro.International journal of experimental pathology · 1995Article
- The relationship between the number of nuclei of an osteoclast and its resorptive capability in vitro.Anatomy and embryology · 1992Article
- An assessment of the ability of human bone marrow cultures to generate osteoclasts.International journal of experimental pathology · 1992Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Although Paget's disease is the most flagrant example of a primary osteoclast disorder, little is known of osteoclast biology in this disease. In this report we have studied the formation of cells with the osteoclast phenotype in long-term cultures of marrow mononuclear cells derived from patients with Paget's disease, and compared these with similar cells formed in long-term marrow cultures from normal individuals, and with osteoclasts present in pagetic bone. Osteoclasts formed in pagetic marrow cultures resembled osteoclasts present in pagetic bone, but were distinctly different from osteoclasts formed in normal marrow cultures. Osteoclast formation was 10-20-fold greater in pagetic marrow cultures than in normal cultures. The multinucleated cells formed in cultures of pagetic marrow were much larger in size, were hyperresponsive to 1,25(OH)2 vitamin D, had more nuclei per cell, had increased levels of tartrate-resistant acid phosphatase activity and had ultrastructural features which were not seen in multinucleated cells formed from normal marrow mononuclear cells. These pagetic marrow-derived multinucleated cells formed large resorption lacunae on calcified matrices and cross-reacted with monoclonal antibodies which preferentially bind to osteoclasts. The multinucleated cells formed from marrow obtained from uninvolved sites in Paget's patients also displayed these abnormal features.
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