ArticleScientific reports2012
A proton shelter inspired by the sugar coating of acidophilic archaea.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Vesicular and Planar Membranes of Archaea Lipids: Unusual Physical Properties and Biomedical Applications.International journal of molecular sciences · 2022Review
- The Cell Membrane ofInternational journal of molecular sciences · 2020Review
- Lipid remodeling under acidic conditions and its interplay with low Pi stress in Arabidopsis.Plant molecular biology · 2019Article
- Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy.Drug delivery · 2018Article
- Heat Stress Dictates Microbial Lipid Composition along a Thermal Gradient in Marine Sediments.Frontiers in microbiology · 2017Article
- Cell Membrane Fatty Acid Composition ofFrontiers in microbiology · 2017Article
- Identifying Potential Mechanisms Enabling Acidophily in the Ammonia-Oxidizing Archaeon "Candidatus Nitrosotalea devanaterra".Applied and environmental microbiology · 2016Article
- The novel extremely acidophilic, cell-wall-deficient archaeon Cuniculiplasma divulgatum gen. nov., sp. nov. represents a new family, Cuniculiplasmataceae fam. nov., of the order Thermoplasmatales.International journal of systematic and evolutionary microbiology · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acidophilic archaeons are a group of single-celled microorganisms that flourish in hot acid springs (usually pH < 3) but maintain their internal pH near neutral. Although there is a lack of direct evidence, the abundance of sugar modifications on the cell surface has been suggested to provide the acidophiles with protection against proton invasion. In this study, a hydroxyl (OH)-rich polymer brush layer was prepared to mimic the OH-rich sugar coating. Using a novel pH-sensitive dithioacetal molecule as a probe, we studied the proton-resisting property and found that a 10-nm-thick polymer layer was able to raise the pH from 1.0 to > 5.0, indicating that the densely packed OH-rich layer is a proton shelter. As strong evidence for the role of sugar coatings as proton barriers, this biomimetic study provides insight into evolutionary biology, and the results also could be expanded for the development of biocompatible anti-acid materials.
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