ArticlePloS one2012
A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A single tertiary hospital-based retrospective observational study on epidemiological features and clinical correlates of severe pediatricTranslational pediatrics · 2026Article
- Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease.Immune network · 2025Review
- Prognostic analysis of concurrent Pneumocystis jirovecii pneumonia in patients with systemic lupus erythematosus: a retrospective study.BMC infectious diseases · 2024Article
- Local complement activation and modulation in mucosal immunity.Mucosal immunology · 2024Review
- Silent neonatal influenza A virus infection primes systemic antimicrobial immunity.Frontiers in immunology · 2023Article
- Prophylactic Multi-Subunit Vaccine againstVaccines · 2021Article
- Analysis of complement deposition and processing on Chlamydia trachomatis.Medical microbiology and immunology · 2021Article
- Complement andFrontiers in immunology · 2021Article
- Complement andFrontiers in immunology · 2021Article
- Opsonophagocytosis of Chlamydia pneumoniae by Human Monocytes and Neutrophils.Infection and immunity · 2020Article
- An Ancient Molecular Arms Race:Frontiers in immunology · 2020Review
- Article
- Simultaneous Intramuscular And Intranasal Administration Of Chitosan Nanoparticles-AdjuvantedInternational journal of nanomedicine · 2019Article
- Immunity against the Obligate Intracellular Bacterial Pathogen Rickettsia australis Requires a Functional Complement System.Infection and immunity · 2018Article
- Article
- Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model.Oxidative medicine and cellular longevity · 2017Article
- Article
- CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice.European journal of microbiology & immunology · 2015Article
- A re-evaluation of the role of B cells in protective immunity to Chlamydia infection.Immunology letters · 2015Review
- Complement modulation of T cell immune responses during homeostasis and disease.Journal of leukocyte biology · 2014Review
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complement system modulates the intensity of innate and specific immunity. While it protects against infections by extracellular bacteria its role in infection with obligate intracellular bacteria, such as the avian and human pathogen Chlamydia (C.) psittaci, is still unknown. In the present study, knockout mice lacking C3 and thus all main complement effector functions were intranasally infected with C. psittaci strain DC15. Clinical parameters, lung histology, and cytokine levels were determined. A subset of infections was additionally performed with mice lacking C5 or C5a receptors. Complement activation occurred before symptoms of pneumonia appeared. Mice lacking C3 were ∼100 times more susceptible to the intracellular bacteria compared to wild-type mice, with all C3(-/-) mice succumbing to infection after day 9. At a low infective dose, C3(-/-) mice became severely ill after an even longer delay, the kinetics suggesting a so far unknown link of complement to the adaptive, protective immune response against chlamydiae. The lethal phenotype of C3(-/-) mice is not based on differences in the anti-chlamydial IgG response (which is slightly delayed) as demonstrated by serum transfer experiments. In addition, during the first week of infection, the absence of C3 was associated with partial protection characterized by reduced weight loss, better clinical score and lower bacterial burden, which might be explained by a different mechanism. Lack of complement functions downstream of C5 had little effect. This study demonstrates for the first time a strong and complex influence of complement effector functions, downstream of C3 and upstream of C5, on the outcome of an infection with intracellular bacteria, such as C. psittaci.
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