ArticlePloS one2012
Proteinuria triggers renal lymphangiogenesis prior to the development of interstitial fibrosis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Serum soluble LYVE1 is a promising non-invasive biomarker of renal fibrosis: a population-based retrospective cross-sectional study.Immunologic research · 2024Article
- Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats.Scientific reports · 2024Article
- Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury.Journal of the American Society of Nephrology : JASN · 2024Article
- Single Cell Analysis of Lung Lymphatic Endothelial Cells and Lymphatic Responses during Influenza Infection.Journal of respiratory biology and translational medicine · 2024Article
- Increased Lymphatic Vessels: A Risk Factor for Severe Renal Function Loss in Obstructive Nephropathy Patients.International journal of medical sciences · 2024Article
- Angiogenesis-An Emerging Role in Organ Fibrosis.International journal of molecular sciences · 2023Review
- Role of the Renal Lymphatic System in Heart Failure.Current heart failure reports · 2023Review
- Lymphangiogenesis and Lymphatic Barrier Dysfunction in Renal Fibrosis.International journal of molecular sciences · 2022Review
- Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics.International journal of molecular sciences · 2022Article
- The lymphatics in kidney health and disease.Nature reviews. Nephrology · 2021Review
- High-Density Lipoproteins in Kidney Disease.International journal of molecular sciences · 2021Review
- Emerging roles for lymphatics in acute kidney injury: Beneficial or maleficent?Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Lymphatic Reconstruction in Kidney Allograft Aggravates Chronic Rejection by Promoting Alloantigen Presentation.Frontiers in immunology · 2021Article
- Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney Diseases.Journal of the American Society of Nephrology : JASN · 2020Review
- Article
- Sonic hedgehog selectively promotes lymphangiogenesis after kidney injury through noncanonical pathway.American journal of physiology. Renal physiology · 2019Article
- Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage.International journal of molecular sciences · 2019Article
- Lymphangiogenesis in kidney and lymph node mediates renal inflammation and fibrosis.Science advances · 2019Article
- Immune cell trafficking, lymphatics and hypertension.British journal of pharmacology · 2019Review
- Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice.Cell death & disease · 2019Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteinuria is an important cause of progressive tubulo-interstitial damage. Whether proteinuria could trigger a renal lymphangiogenic response has not been established. Moreover, the temporal relationship between development of fibrosis, inflammation and lymphangiogenesis in chronic progressive kidney disease is not clear yet. Therefore, we evaluated the time course of lymph vessel (LV) formation in relation to proteinuria and interstitial damage in a rat model of chronic unilateral adriamycin nephrosis. Proteinuria and kidneys were evaluated up to 30 weeks after induction of nephrosis. LVs were identified by podoplanin/VEGFR3 double staining. After 6 weeks proteinuria was well-established, without influx of interstitial macrophages and myofibroblasts, collagen deposition, osteopontin expression (tubular activation) or LV formation. At 12 weeks, a ∼3-fold increase in cortical LV density was found (p<0.001), gradually increasing over time. This corresponded with a significant increase in tubular osteopontin expression (p<0.01) and interstitial myofibroblast numbers (p<0.05), whereas collagen deposition and macrophage numbers were not yet increased. VEGF-C was mostly expressed by tubular cells rather than interstitial cells. Cultured tubular cells stimulated with FCS showed a dose-dependent increase in mRNA and protein expression of VEGF-C which was not observed by human albumin stimulation. We conclude that chronic proteinuria provoked lymphangiogenesis in temporal conjunction with tubular osteopontin expression and influx of myofibroblasts, that preceded interstitial fibrosis.
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