ArticlePloS one2012
Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Role of thymic stromal lymphopoietin in allergy and beyond.Nature reviews. Immunology · 2023Review
- Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.Scientific reports · 2022Article
- Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models.Frontiers in immunology · 2022Review
- Resolution of viral load in mild COVID-19 patients is associated with both innate and adaptive immune responses.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022Article
- Article
- Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker.Frontiers in immunology · 2019Review
- Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.Nature communications · 2018Article
- Article
- Interleukin-7 in the transition of bone marrow progenitors to the thymus.Immunology and cell biology · 2017Article
- Topical CpG Oligodeoxynucleotide Adjuvant Enhances the Adaptive Immune Response against Influenza A Infections.Frontiers in immunology · 2016Article
- Balancing Immune Protection and Immune Pathology by CD8(+) T-Cell Responses to Influenza Infection.Frontiers in immunology · 2016Review
- A direct and nonredundant role for thymic stromal lymphopoietin on antiviral CD8 T cell responses in the respiratory mucosa.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.PLoS pathogens · 2014Article
- Every breath you take: the impact of environment on resident memory CD8 T cells in the lung.Frontiers in immunology · 2014Review
- The development and survival but not function of follicular B cells is dependent on IL-7Rα Tyr449 signaling.PloS one · 2014Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The immune response to viral infection is ideally rapid and specific, resulting in viral clearance and establishment of immune memory. Some viruses such as HIV can evade such responses leading to chronic infection, while others like Influenza A can elicit a severe inflammatory response with immune-related complications including death. Cytokines play a major role in shaping the appropriate outcomes to infection. While Interleukin-7 (IL-7) has a critical role in T and B cell development, treatment with IL-7 has recently been shown to aid the adaptive T cell response in clearance of chronic viral infection. In contrast, the IL-7-related cytokine thymic stromal lymphopoietin (TSLP) has a limited role in lymphocyte development but is important in the immune response to parasitic worms and allergens. The role for these cytokines in the immune response to an acute viral infection is unclear. IL-7 and TSLP share IL-7Rα as part of their heterodimeric receptors with the gamma common chain (γc) and TSLPR, respectively. We investigated the role of IL-7 and TSLP in the primary immune response to influenza A infection using hypomorphic IL-7Rα (IL-7Rα(449F)) and TSLPR(-/-) mice. We found that IL-7, but not TSLP, plays an important role in control of influenza A virus. We also showed that IL-7 signaling was necessary for the generation of a robust influenza A-specific CD4 and CD8 T cell response and that this requirement is intrinsic to CD8 T cells. These findings demonstrate a significant role for IL-7 during acute viral infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.