Trial reportPloS one2012
No effect of a single session of transcranial direct current stimulation on experimentally induced pain in patients with chronic low back pain--an exploratory study.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05757609 (Innovative Non-invasive Brain Stimulation in the Rehabilitation of Patients With Chronic Low Back Pain), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Innovative Non-invasive Brain Stimulation in the Rehabilitation of Patients With Chronic Low Back Pain
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evidence-Based Guidelines and Secondary Meta-Analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric Disorders.The international journal of neuropsychopharmacology · 2021Pooled it
- Is transcranial direct current stimulation (tDCS) effective for chronic low back pain? A systematic review and meta-analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2020Pooled it
- Transcranial direct current stimulation (a-tCDS) after subacromial injections in patients with subacromial pain syndrome: a randomized controlled pilot study.BMC musculoskeletal disorders · 2021Trial
- Trial
- Effectiveness of transcranial direct current stimulation preceding cognitive behavioural management for chronic low back pain: sham controlled double blinded randomised controlled trial.BMJ (Clinical research ed.) · 2015Trial
- Analgesic efficacy of cerebral and peripheral electrical stimulation in chronic nonspecific low back pain: a randomized, double-blind, factorial clinical trial.BMC musculoskeletal disorders · 2015Trial
- Building up analgesia in humans via the endogenous μ-opioid system by combining placebo and active tDCS: a preliminary report.PloS one · 2014Trial
- Exploring the therapeutic potential of transcranial direct current stimulation for chronic low back pain: a scoping review.European journal of physical and rehabilitation medicine · 2025Article
- Article
- Effects of High-Definition Transcranial Direct Current Stimulation Over the Primary Motor Cortex on Cold Pain Sensitivity Among Healthy Adults.Frontiers in molecular neuroscience · 2022Article
- Non-invasive brain neuromodulation techniques for chronic low back pain.Frontiers in molecular neuroscience · 2022Review
- Brain Circuits Involved in the Development of Chronic Musculoskeletal Pain: Evidence From Non-invasive Brain Stimulation.Frontiers in neurology · 2021Review
- Bilateral Motor Cortex tDCS Effects on Post-Stroke Pain and Spasticity: A Three Cases Study.Frontiers in pharmacology · 2021Article
- Does Transcranial Direct Current Stimulation Combined with Peripheral Electrical Stimulation Have an Additive Effect in the Control of Hip Joint Osteonecrosis Pain Associated with Sickle Cell Disease? A Protocol for a One-Session Double Blind, Block-Randomized Clinical Trial.Frontiers in human neuroscience · 2017Article
- Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain.Stem cells international · 2016Article
- Combined neuromodulatory interventions in acute experimental pain: assessment of melatonin and non-invasive brain stimulation.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial direct current stimulation (tDCS) has been shown to modulate cortical excitability. A small number of studies suggested that tDCS modulates the response to experimental pain paradigms. No trials have been conducted to evaluate the response of patients already suffering from pain, to an additional experimental pain before and after tDCS. The present study investigated the effect of a single session of anodal, cathodal and sham stimulation (15 mins/1 mA) over the primary motor cortex on the perceived intensity of repeated noxious thermal and electrical stimuli and on elements of quantitative sensory testing (thermal pain and perception thresholds) applied to the right hand in 15 patients with chronic low back pain. The study was conducted in a double-blind sham-controlled and cross-over design. No significant alterations of pain ratings were found. Modalities of quantitative sensory testing remained equally unchanged. It is therefore hypothesized that a single 15 mins session of tDCS at 1 mA may not be sufficient to alter the perception of experimental pain and in patients with chronic pain. Further studies applying repetitive tDCS to patients with chronic pain are required to fully answer the question whether experimental pain perception may be influenced by tDCS over the motor cortex.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.