ArticleFrontiers in neural circuits2012
Closing the loop in primate prefrontal cortex: inter-laminar processing.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A Systematic Review of Closed-Loop Feedback Techniques in Sleep Studies-Related Issues and Future Directions.Sensors (Basel, Switzerland) · 2020Pooled it
- Optimized Real-Time Biomimetic Neural Network on FPGA for Bio-hybridization.Frontiers in neuroscience · 2019Article
- Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates.Radiation research · 2017Article
- What Is the Evidence for Inter-laminar Integration in a Prefrontal Cortical Minicolumn?Frontiers in neuroanatomy · 2017Article
- A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain.Experimental neurology · 2017Article
- Erratum to: Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Article
- Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Review
- Current Challenges Facing the Translation of Brain Computer Interfaces from Preclinical Trials to Use in Human Patients.Frontiers in cellular neuroscience · 2015Review
- Advancing brain-machine interfaces: moving beyond linear state space models.Frontiers in systems neuroscience · 2015Article
- Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure.Frontiers in systems neuroscience · 2015Article
- Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing.Brain : a journal of neurology · 2014Review
- A computational model for the loss of neuronal organization in microcolumns.Biophysical journal · 2014Article
- Volitional enhancement of firing synchrony and oscillation by neuronal operant conditioning: interaction with neurorehabilitation and brain-machine interface.Frontiers in systems neuroscience · 2014Review
- Closed-loop neuroscience and neuroengineering.Frontiers in neural circuits · 2014Article
- Nanostructures: a platform for brain repair and augmentation.Frontiers in systems neuroscience · 2014Review
- Brain-machine interfaces can accelerate clarification of the principal mysteries and real plasticity of the brain.Frontiers in systems neuroscience · 2014Article
- Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing.Journal of neural engineering · 2013Article
- In vitro large-scale experimental and theoretical studies for the realization of bi-directional brain-prostheses.Frontiers in neural circuits · 2013Article
- Prefrontal cortical microcircuits bind perception to executive control.Scientific reports · 2013Article
- Inter-laminar microcircuits across neocortex: repair and augmentation.Frontiers in systems neuroscience · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Prefrontal cortical (PFC) activity in the primate brain emerging from minicolumnar microcircuits plays a critical role in cognitive processes dealing with executive control of behavior. However, the specific operations of columnar laminar processing in prefrontal cortex (PFC) are not completely understood. Here we show via implementation of unique microanatomical recording and stimulating arrays, that minicolumns in PFC are involved in the executive control of behavior in rhesus macaque nonhuman primates (NHPs) performing a delayed-match-to-sample (DMS) task. PFC neurons demonstrate functional interactions between pairs of putative pyramidal cells within specified cortical layers via anatomically oriented minicolumns. Results reveal target-specific, spatially tuned firing between inter-laminar (layer 2/3 and layer 5) pairs of neurons participating in the gating of information during the decision making phase of the task with differential correlations between activity in layer 2/3 and layer 5 in the integration of spatial vs. object-specific information for correct task performance. Such inter-laminar processing was exploited by the interfacing of an online model which delivered stimulation to layer 5 locations in a pattern associated with successful performance thereby closing the columnar loop externally in a manner that mimicked normal processing in the same task. These unique technologies demonstrate that PFC neurons encode and process information via minicolumns which provides a closed loop form of "executive function," hence disruption of such inter-laminar processing could form the bases for cognitive dysfunction in primate brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.