Evidence map›Paper›PMID 23188882›Full record

ArticleAutism : the international journal of research and practice2014

Sex differences and within-family associations in the broad autism phenotype.

Jessica Klusek, Molly Losh, Gary E Martin

Open access · greenAbstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 51 citations in OpenAlex.

  1. The impact of individual factors on linguistic alignment of autistic boys and their mothers.Autism : the international journal of research and practice · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Narrative Ability in Autism and First-Degree Relatives.Journal of autism and developmental disorders · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Neural Processing of Speech Sounds in ASD and First-Degree Relatives.Journal of autism and developmental disorders · 2023
    Article
  11. Review
  12. Article
  13. The FMR1 Premutation Phenotype and Mother-Youth Synchrony in Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Social (Pragmatic) Communication Disorder: Another name for the Broad Autism Phenotype?Autism : the international journal of research and practice · 2019
    Article
  19. Article
  20. Family Emotional Climate and Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jessica Klusek1Frank Porter Graham Child Development Institute, USA and University of North Carolina at Chapel Hill, USA.
Molly Losh
Gary E Martin
University of North Carolina at Chapel Hill · USNorthwestern University · US

Funding

UNC MRDD Research CenterP30HD003110 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL · 1985 to 2012
$28.7M
A Family-Genetic Study of Autism and Fragile X SyndromeR01MH091131 · NIMH · NORTHWESTERN UNIVERSITY · PI Molly C Losh · 2012 to 2026
$10.1M
A Family-Genetic Study of Language in AutismR01DC010191 · NIDCD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Molly C Losh · 2010 to 2026
$7.8M
NICHD NIH HHS P30 HD003110NIDCD NIH HHS 1R01DC010191-01A1NIDCD NIH HHS R01 DC010191NIMH NIH HHS R01 MH091131
6 · The paper itself

Abstract

While there is a strong sex bias in the presentation of autism, it is unknown whether this bias is also present in subclinical manifestations of autism among relatives, or the broad autism phenotype. This study examined this question and investigated patterns of co-occurrence of broad autism phenotype traits within families of individuals with autism. Pragmatic language and personality features of the broad autism phenotype were studied in 42 fathers and 50 mothers of individuals with autism using direct assessment tools used in prior family studies of the broad autism phenotype. Higher rates of aloof personality style were detected among fathers, while no sex differences were detected for other broad autism phenotype traits. Within individuals, pragmatic language features were associated with the social personality styles of the broad autism phenotype in mothers but not in fathers. A number of broad autism phenotype features were correlated within spousal pairs. Finally, the associations were detected between paternal broad autism phenotype characteristics and the severity of children's autism symptoms in all three domains (social, communication, and repetitive behaviors). Mother-child correlations were detected for aspects of communication only. Together, the findings suggest that most features of the broad autism phenotype express comparably in males and females and raise some specific questions about how such features might inform studies of the genetic basis of autism.

Indexed as

EndophenotypesPersonalityAdolescentAdultAutistic DisorderChildCommunicationFamilyFathersFemaleHumansLanguageMaleMiddle AgedMothersPhenotypeautismbroad autism phenotypeendophenotypegenderpersonalitypragmatic languagesex

Identifiers

PMID23188882
PMCPMC3703490
OpenAlexW2154372634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.