ArticlePlant physiology2013
Functional divergence of the glutathione S-transferase supergene family in Physcomitrella patens reveals complex patterns of large gene family evolution in land plants.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 165 citations in OpenAlex.
- Large-scale genomic analysis reveals the origin and evolution of Glutathione S-transferases (GSTs) in plants.BMC genomics · 2026Article
- Reversible phase dynamics of PsAF5 regulate mitophagy to balance redox levels inScience advances · 2026Article
- Genome-wide analysis of the glutathione S-transferase family inFrontiers in plant science · 2026Article
- A Review of Bryophytes: Enzymatic and Non-Enzymatic Antioxidants as a Key for Their Pharmacological Potential and Green-Biotechnological Application.Antioxidants (Basel, Switzerland) · 2025Review
- Genome-wide identification and abiotic stress responses of3 Biotech · 2025Article
- Cytochrome c oxidase inactivation in Physcomitrium patens reveals that respiration coordinates plant metabolism.The Plant cell · 2025Article
- Genome-wide identification, expression and functional analysis of glutathioneFrontiers in plant science · 2025Article
- Genome-wide identification and in silico analysis of GSTs reveals hormone mediated stress response in saffron.Frontiers in plant science · 2025Article
- Overlooked and misunderstood: can glutathione conjugates be clues to understanding plant glutathione transferases?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Genome-Wide Identification of Glutathione S-Transferase Family fromInternational journal of molecular sciences · 2024Article
- Identification and Characterization of the Glutathione S-Transferase Gene Family in Blueberry (Plants (Basel, Switzerland) · 2024Article
- Glutathione Transferases Are Involved in the Genotype-Specific Salt-Stress Response of Tomato Plants.Antioxidants (Basel, Switzerland) · 2023Article
- Genome-wide identification and characterization of glutathione3 Biotech · 2023Article
- PgMYB1 Positively Regulates Anthocyanin Accumulation by ActivatingInternational journal of molecular sciences · 2023Article
- Genome-wide in silico identification of glutathione S-transferase (GST) gene family members in fig (PeerJ · 2023Review
- Article
- Ascorbate-Glutathione Cycle Genes Families in Euphorbiaceae: Characterization and Evolutionary Analysis.Biology · 2022Article
- Genome-wide identification and characterization of glutathione S-transferase gene family in Musa acuminata L. AAA group and gaining an insight to their role in banana fruit development.Journal of applied genetics · 2022Article
- Computational insights into diverse aspects of glutathione S-transferase gene family in Papaver somniferum.Journal of plant research · 2022Article
- AtGSTU19 and AtGSTU24 as Moderators of the Response ofInternational journal of molecular sciences · 2022Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant glutathione S-transferases (GSTs) are multifunctional proteins encoded by a large gene family that play major roles in the detoxification of xenobiotics and oxidative stress metabolism. To date, studies on the GST gene family have focused mainly on vascular plants (particularly agricultural plants). In contrast, little information is available on the molecular characteristics of this large gene family in nonvascular plants. In addition, the evolutionary patterns of this family in land plants remain unclear. In this study, we identified 37 GST genes from the whole genome of the moss Physcomitrella patens, a nonvascular representative of early land plants. The 37 P. patens GSTs were divided into 10 classes, including two new classes (hemerythrin and iota). However, no tau GSTs were identified, which represent the largest class among vascular plants. P. patens GST gene family members showed extensive functional divergence in their gene structures, gene expression responses to abiotic stressors, enzymatic characteristics, and the subcellular locations of the encoded proteins. A joint phylogenetic analysis of GSTs from P. patens and other higher vascular plants showed that different class GSTs had distinct duplication patterns during the evolution of land plants. By examining multiple characteristics, this study revealed complex patterns of evolutionary divergence among the GST gene family in land plants.
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