Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
A strategy of symptom-limited exercise with regadenoson-as-needed for stress myocardial perfusion imaging: a randomized controlled trial.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- The EXXERT Study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Trial
- Aminophylline and caffeine for reversal of adverse symptoms associated with regadenoson SPECT MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Trial
- The EXERRT trial: "EXErcise to Regadenoson in Recovery Trial": A phase 3b, open-label, parallel group, randomized, multicenter study to assess regadenoson administration following an inadequate exercise stress test as compared to regadenoson without exercise for myocardial perfusion imaging using a SPECT protocol.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Trial
- The impact of combination of regadenoson and isometric exercise on image quality of myocardial perfusion scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Regadenoson stress during low-level exercise: The EXERRT trial-does it move the needle?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- A helping hand for regadenoson tests.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- A useful and easy to develop combined stress test for myocardial perfusion imaging: Regadenoson and isometric exercise, preliminary results.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Influence of cardiac stress protocol on myocardial perfusion imaging accuracy: The role of exercise level on the evaluation of ischemic burden.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Serious and potentially life threatening complications of cardiac stress testing: Physiological mechanisms and management strategies.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- New exercise-dipyridamole combined test for nuclear cardiology in insufficient effort: appropriate diagnostic sensitivity keeping exercise prognosis.Arquivos brasileiros de cardiologia · 2015Article
- Does risk for major adverse cardiac events in patients undergoing vasodilator stress with adjunctive exercise differ from patients undergoing either standard exercise or vasodilator stress with myocardial perfusion imaging?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Cardiovascular risk stratification in diabetic patients following stress single-photon emission-computed tomography myocardial perfusion imaging: the impact of achieved exercise level.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Regadenoson for myocardial perfusion imaging: Is it safe?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Is regadenoson an appropriate stressor for MPI in patients with left bundle branch block or pacemakers?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Regadenoson and exercise myocardial perfusion imaging: the courtship continues.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Off-label, but on-target: use of regadenoson with exercise.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
Corrections and comments
- Commented on by
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmbulatory patients with uncertain functional capacity may benefit from combined exercise and vasodilator stress protocols for myocardial perfusion imaging (MPI). The safety and MPI image quality with regadenoson administered during symptom-limited exercise have not been prospectively evaluated. METHODS AND
resultsA total of 140 patients (mean age 61 years, 48% female) referred for exercise with vasodilator stress MPI were randomized 2:1 to a strategy of exercise with regadenoson-as-necessary (Ex-Reg, n = 96) or dipyridamole with exercise (Dip-Ex, n = 44) after Duke Activity Status Index (DASI) scoring (median score 28 vs 24, P = .09). Ex-Reg subjects commenced treadmill exercise and regadenoson was administered only if the subject was unable to reach standard endpoints. Dip-Ex subjects received dipyridamole prior to symptom-limited exercise. Hemodynamics were recorded throughout. Subjects completed symptom questionnaires and MPI image quality was assessed by blinded read. Ex-Reg subjects were more likely to achieve ≥85% age-predicted maximum heart rate than Dip-Ex subjects (57% vs 32%, P < .01). Only 50% of subjects meeting inclusion criteria and randomized to Ex-Reg required regadenoson and none had symptomatic hemodynamic changes. Severe side effects or adverse events occurred in 16% of Ex-Reg and 24% of Dip-Ex subjects (P = .12). MPI image quality was "good" or "excellent" in 88% of Ex-Reg subjects and 86% of Dip-Ex subjects (P = .33).
conclusionA strategy of exercise with regadenoson-as-needed for MPI offers similar safety and side effect profile with similar image quality compared to dipyridamole with exercise, with reduced pharmaceutical use.
Indexed as
Identifiers
23188626What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.