ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2013
Inflaming the brain: CRPS a model disease to understand neuroimmune interactions in chronic pain.
Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Haematologic Data Improves Long-Term Prediction Accuracy of Artificial Intelligence Models for Temporomandibular Disorders.Journal of oral rehabilitation · 2025Article
- Hematological biomarkers of systemic inflammation in predicting long-term treatment response of temporomandibular disorders.BMC oral health · 2024Article
- Identification of Potential Inflammation-Related Genes and Key Pathways Associated with Complex Regional Pain Syndrome.Biomolecules · 2023Article
- The Role of Neuroinflammation in Complex Regional Pain Syndrome: A Comprehensive Review.Journal of pain research · 2023Review
- Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome.Journal of neuroinflammation · 2019Article
- Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors.Biological psychiatry · 2019Article
- Anti-allodynic effect of interleukin 10 in a mouse model of complex regional pain syndrome through reduction of NK1 receptor expression of microglia in the spinal cord.Journal of pain research · 2018Article
- Complex regional pain syndrome: The matter of white matter?Brain and behavior · 2017Article
- [11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study.Medicine · 2017Article
- Acute versus chronic phase mechanisms in a rat model of CRPS.Journal of neuroinflammation · 2016Article
- Article
- Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome.Nature reviews. Rheumatology · 2015Review
- PET and MR imaging of neuroinflammation in hepatic encephalopathy.Metabolic brain disease · 2015Review
- Brain neuroplastic changes accompany anxiety and memory deficits in a model of complex regional pain syndrome.Anesthesiology · 2014Article
- Article
- Differential neuropathic pain sensitivity and expression of spinal mediators in Lewis and Fischer 344 rats.BMC neuroscience · 2014Article
- Acute and chronic phases of complex regional pain syndrome in mice are accompanied by distinct transcriptional changes in the spinal cord.Molecular pain · 2013Article
- Treatment of Complex Regional Pain Syndrome (CRPS) using low dose naltrexone (LDN).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- Imaging biomarkers and the role of neuroinflammation in neuropathic pain.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We review current concepts in CRPS from a neuroimaging perspective and point out topics and potential mechanisms that are suitable to be investigated in the next step towards understanding the pathophysiology of CRPS. We have outlined functional aspects of the syndrome, from initiating lesion via inflammatory mechanisms to CNS change and associated sickness behavior, with current evidence for up-regulation of immunological factors in CRPS, neuroimaging of systemic inflammation, and neuroimaging findings in CRPS. The initiation, maintenances and CNS targets implicated in CRPS and in the neuro-inflammatory reflex are discussed in terms of CRPS symptoms and recent preclinical studies. Potential avenues for investigating CRPS with PET and fMRI are described, along with roles of inflammation, treatment and behavior in CRPS. It is our hope that this outline will provoke discussion and promote further empirical studies on the interactions between central and peripheral inflammatory pathways manifest in CRPS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.