ArticleAnnals of nuclear medicine2013
Dual-time-point F-18 FDG PET/CT imaging for differentiating the lymph nodes between malignant lymphoma and benign lesions.
Article in Annals of nuclear medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- ESR Innovation in Focus: Long-axial field-of-view PET/CT.European radiology · 2026Article
- Exploring extended [European journal of nuclear medicine and molecular imaging · 2026Article
- Differentiating lymphoma progression from benign lesions: features of incident [Frontiers in medicine · 2026Article
- Lymphoproliferative Disorders Mimicking Rheumatologic Disease: A Clinical Reasoning Perspective.Current allergy and asthma reports · 2025Review
- Long-Axial Field-of-View PET Imaging in Patients with Lymphoma: Challenges and Opportunities.PET clinics · 2024Review
- Estimation of kinetic parameters in dynamic FDG PET imaging based on shortened protocols: a virtual clinical study.Physical and engineering sciences in medicine · 2024Article
- Diagnostic Superiority of Dual-Time Point [Diagnostics (Basel, Switzerland) · 2023Article
- The utility ofReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Article
- Detection of clinically silent brain lesions in [18F]FDG PET/CT study in oncological patients: analysis of over 10,000 studies.Scientific reports · 2021Article
- Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography and Magnetic Resonance Imaging for Adverse Local Tissue Reactions near Metal Implants after Total Hip Arthroplasty: A Preliminary Report.Clinics in orthopedic surgery · 2021Article
- Initial and Delayed Metabolic Activity of Palatine Tonsils Measured with the PET/CT-Dedicated Parameters.Diagnostics (Basel, Switzerland) · 2020Article
- The clinical value of texture analysis of dual-time-pointEuropean radiology · 2020Article
- Dual time point [18F]Flurodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) with water gastric distension in differentiation between malignant and benign gastric lesions.European journal of radiology open · 2020Article
- Review
- Change in standardized uptake values in delayed 18F-FDG positron emission tomography images in hepatocellular carcinoma.Medicine · 2018Article
- The role of dual time point PET/CT for distinguishing malignant from benign focal 18F-FDG uptake duodenal lesions.Medicine · 2018Article
- Relationship Between Dual Time Point FDG PET/CT and Clinical Prognostic Indexes in Patients with High Grade Lymphoma: a Pilot Study.Nuclear medicine and molecular imaging · 2017Article
- Dual time-pointOncotarget · 2017Article
- Dual time-point FDG PET/CT and FDG uptake and related enzymes in lymphadenopathies: preliminary results.European journal of nuclear medicine and molecular imaging · 2016Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of the present study is to evaluate the clinical value of dual-time-point F-18 FDG PET/CT imaging to differentiate malignant lymphoma (ML) from benign lymph node (BLN). MATERIALS AND
methodsThe subjects were 310 lymph nodes in 84 patients (195 ML lesions in 30 patients and 115 BLN in 54 patients associated with various etiologies.). F-18 FDG PET/CT scan was performed at 50 min (early scan) and at 100 min (delayed scan) after the injection. First, the maximum standardized uptake value (SUVmax) of each lesion at early and delayed scans was calculated. Second, we estimated the difference between early and delayed SUVmax (D-SUVmax) and the retention index (RI-SUVmax) to evaluate the change of tracers in the lesions. Furthermore, proper cut-off values of them were evaluated using receiver operating characteristic analysis. The efficacy of each parameter was analyzed with ANOVA.
resultsDelayed SUVmax and D-SUVmax in ML were significantly higher than those in BLN. Proper cut-off value in delayed SUVmax was 4.0 and in D-SUVmax was 1.0. When the proper cut-off value in D-SUVmax was applied, the D-SUVmax yielded the role of diagnosis with sensitivity of 82.6%, specificity of 65.2%, positive predictive value of 80.1% and negative predictive value of 68.8%, respectively.
conclusionsThe delayed SUVmax and D-SUVmax were useful indices to differentiate ML from BLN, regardless of histologic subtype. Dual-time-point F-18 FDG PET/CT imaging may help to consider whether there is any need to proceed to more invasive tests, such as biopsy, in individual patients.
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