ArticleEuropean journal of human genetics : EJHG2013
Non-invasive prenatal testing for single gene disorders: exploring the ethics.
Article in European journal of human genetics : EJHG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Non-invasive prenatal diagnosis for cystic fibrosis: detection of paternal mutations, exploration of patient preferences and cost analysis.Prenatal diagnosis · 2015Trial
- Reviewing the Genetic and Molecular Foundations of Congenital Spinal Deformities: Implications for Classification and Diagnosis.Journal of clinical medicine · 2025Review
- Is routine prenatal screening and testing fundamentally incompatible with a commitment to reproductive choice? Learning from the historical context.Medicine, health care, and philosophy · 2021Article
- Noninvasive prenatal testing: from aneuploidy to single genes.Human genetics · 2020Review
- 'Small cost to pay for peace of mind': Women's experiences with non-invasive prenatal testing.The Australian & New Zealand journal of obstetrics & gynaecology · 2019Article
- Interpretations of autonomous decision-making in antenatal genetic screening among women in China, Hong Kong and Pakistan.European journal of human genetics : EJHG · 2018Article
- Opening Pandora's box?: ethical issues in prenatal whole genome and exome sequencing.Prenatal diagnosis · 2018Review
- Preferences for prenatal diagnosis of sickle-cell disorder: A discrete choice experiment comparing potential service users and health-care providers.Health expectations : an international journal of public participation in health care and health policy · 2017Article
- Genetic Counseling for Couples Seeking Noninvasive Prenatal Testing in Japan: Experiences of Pregnant Women and their Partners.Journal of genetic counseling · 2017Article
- Medical Genetics Ethics Case Collection: Discussion Materials for Medical Students in the Genomic Era.MedEdPORTAL : the journal of teaching and learning resources · 2017Article
- Non-invasive prenatal diagnosis (NIPD) for single gene disorders: cost analysis of NIPD and invasive testing pathways.Prenatal diagnosis · 2016Article
- Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening.European journal of human genetics : EJHG · 2015Article
- An easy test but a hard decision: ethical issues concerning non-invasive prenatal testing for autosomal recessive disorders.European journal of human genetics : EJHG · 2015Article
- Non-invasive prenatal testing: a review of international implementation and challenges.International journal of women's health · 2015Review
- How people in Benin assess a couple's risk of having a baby with sickle cell disease.Journal of community genetics · 2015Article
- Client views and attitudes to non-invasive prenatal diagnosis for sickle cell disease, thalassaemia and cystic fibrosis.Journal of genetic counseling · 2014Article
- Preferences for Prenatal Tests for Cystic Fibrosis: A Discrete Choice Experiment to Compare the Views of Adult Patients, Carriers of Cystic Fibrosis and Health Professionals.Journal of clinical medicine · 2014Article
- Circulating nucleic acids in plasma and serum: applications in diagnostic techniques for noninvasive prenatal diagnosis.International journal of women's health · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Non-invasive prenatal testing for single gene disorders is now clearly on the horizon. This new technology offers obvious clinical benefits such as safe testing early in pregnancy. Before widespread implementation, it is important to consider the possible ethical implications. Four hypothetical scenarios are presented that highlight how ethical ideals of respect for autonomy, privacy and fairness may come into play when offering non-invasive prenatal testing for single gene disorders. The first scenario illustrates the moral case for using these tests for 'information only', identifying a potential conflict between larger numbers of women seeking the benefits of the test and the wider social impact of funding tests that do not offer immediate clinical benefit. The second scenario shows how the simplicity and safety of non-invasive prenatal testing could lead to more autonomous decision-making and, conversely, how this could also lead to increased pressure on women to take up testing. In the third scenario we show how, unless strong safeguards are put in place, offering non-invasive prenatal testing could be subject to routinisation with informed consent undermined and that woman who are newly diagnosed as carriers may be particularly vulnerable. The final scenario introduces the possibility of a conflict of the moral rights of a woman and her partner through testing for single gene disorders. This analysis informs our understanding of the potential impacts of non-invasive prenatal testing for single gene disorders on clinical practice and has implications for future policy and guidelines for prenatal care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.