Evidence map›Paper›PMID 23187956›Full record

Trial reportEuropean journal of clinical nutrition2013

Effect of soybean protein on novel cardiovascular disease risk factors: a randomized controlled trial.

C M Rebholz, K Reynolds, M R Wofford, J Chen, T N Kelly, H Mei, P K Whelton, J He

2 registry-linked trialsAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00046566 nacompletednot on this map

Clinical Trial of Dietary Protein on Blood Pressure

TypeinterventionalSponsorTulane UniversityRan2002 to 2008Enrolled352ConditionsCardiovascular Diseases, Hypertension, Heart DiseasesArmsSoy protein-milk protein-carbohydrate, Milk protein-carbohydrate-soy protein, Carbohydrate-soy protein-milk protein
NCT00107744 nacompletednot on this map

Clinical Trial of Protein and Blood Pressure

TypeinterventionalSponsorTulane UniversityRan2003 to 2008Enrolled352ConditionsHypertension, HypercholesterolemiaArmsSoy protein-milk protein-carbohydrate, Milk protein-carbohydrate-soy protein, Carbohydrate-soy protein-milk protein
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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  13. Frontiers in microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

C M RebholzDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
K Reynolds
M R Wofford
J Chen
T N Kelly
H Mei
P K Whelton
J He
Tulane University · USJackson Memorial Hospital · US

Funding

Clinical Trial of Dietary Protein on Blood PressureR01HL068057 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2006
$2.9M
NHLBI NIH HHS R01 HL068057NHLBI NIH HHS R01 HL68057
6 · The paper itself

Abstract

BACKGROUND/

objectivesCardiovascular disease (CVD) is the leading cause of death in the United States and the world. Clinical trials have suggested that soybean protein lowers lipids and blood pressure. The effect of soybean protein on novel CVD risk factors has not been well studied. The objective of this study was to examine the effect of soybean protein on biomarkers of inflammation, endothelial dysfunction and adipocytokines. SUBJECTS/

methodsThe effect of 8 weeks of 40 g of soybean protein supplement (89.3 mg isoflavones), 40 g of milk protein supplement and 40 g of complex carbohydrate placebo was examined in a randomized, placebo-controlled, double-blind, three-phase crossover trial among adults in New Orleans, Louisiana and Jackson, Mississippi. Plasma levels of inflammation biomarkers (C-reactive protein, interleukin-6, tumor necrosis factor-α), endothelial dysfunction biomarkers (E-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, thrombomodulin) and adipocytokines (high-molecular weight adiponectin, leptin, resistin) were measured at baseline and at the end of each intervention using immunoturbidimetric and enzyme-linked immunosorbent assay techniques.

resultsSoy protein supplementation resulted in a significant mean net change (95% confidence interval) in plasma E-selectin of -3.93 ng/ml (-7.05 to -0.81 ng/ml; P=0.014) compared with milk protein, and in plasma leptin of -2089.8 pg/ml (-3689.3 to -490.3 pg/ml; P=0.011) compared with carbohydrate. There were no significant changes in any other risk factors.

conclusionsSoy protein supplementation may reduce levels of E-selectin and leptin. Further research is warranted to investigate the mechanisms through which protein may confer protective effects on novel CVD risk factors.

Indexed as

Dietary SupplementsAdipokinesAdultBiomarkersCardiovascular DiseasesCross-Over StudiesDouble-Blind MethodEndothelium, VascularE-SelectinFemaleHumansInflammation MediatorsLeptinLouisianaMaleMiddle AgedAdipokinesBiomarkersE-SelectinInflammation MediatorsLeptinMilk ProteinsSELE protein, humanSoybean Proteins

Identifiers

PMID23187956
PMCPMC5511630
OpenAlexW2159621983

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.