Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Disease-specific U1 spliceosomal RNA mutations in mature B-cell neoplasms.Leukemia · 2025
   Article
2. Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets.Cancers · 2021
   Review
3. Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations.Blood · 2020
   Article
4. Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan.Proceedings of the National Academy of Sciences of the United States of America · 2019
   Article
5. Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability.Scientific reports · 2019
   Article
6. SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing.Nucleic acids research · 2017
   Article
7. The molecular pathogenesis of chronic lymphocytic leukaemia.Nature reviews. Cancer · 2016
   Review
8. The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.Oncotarget · 2015
   Article
9. Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B.Haematologica · 2015
   Article
10. Molecular pathogenesis of CLL and its evolution.International journal of hematology · 2015
    Review
11. SF3B1 mutations in chronic lymphocytic leukemia.Blood · 2013
    Review
12. The genomic landscape of chronic lymphocytic leukemia: clinical implications.BMC medicine · 2013
    Review
13. Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics.Genome medicine · 2013
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

12 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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