Evidence map›Paper›PMID 23187135›Full record

ArticleThe Journal of clinical investigation2012

Leaky channels make weak muscles.

Alfred L George

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alfred L GeorgeDepartment of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA. al.george@vanderbilt.edu
Vanderbilt University · US

Funding

HEREDITARY DEFECTS IN HUMAN SODIUM CHANNELSR01NS032387 · NINDS · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L. · 1994 to 2015
$3.2M
Neonatal Long QT Syndrome and Sudden Infant DeathR01HL083374 · NHLBI · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L. · 2007 to 2015
$2.9M
Hereditary Defects in Human Sodium ChannelsR37NS032387 · NINDS · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L. · 2003 to 2009
$2.6M
NHLBI NIH HHS HL083374NHLBI NIH HHS R01 HL083374NINDS NIH HHS NS032387NINDS NIH HHS R01 NS032387NINDS NIH HHS R37 NS032387
6 · The paper itself

Abstract

Mutations in the skeletal muscle voltage-gated calcium channel (CaV1.1) have been associated with hypokalemic periodic paralysis, but how the pathogenesis of this disorder relates to the functional consequences of mutations was unclear. In this issue of the JCI, Wu and colleagues recapitulate the disease by generating a novel knock-in CaV1.1 mutant mouse and use this model to investigate the cellular and molecular features of pathogenesis. They demonstrated an aberrant muscle cell current conducted through the CaV1.1 voltage-sensor domain (gating pore current) that explains an abnormally depolarized muscle membrane and the failure of muscle action potential firing during challenge with agents known to provoke periodic paralysis. Their work advances understanding of molecular and cellular mechanisms underlying an inherited channelopathy.

Indexed as

Mutation, MissenseAnimalsCalcium Channels, L-TypeFemaleHumansHypokalemic Periodic ParalysisMaleMuscle Fibers, SkeletalCACNA1S protein, mouseCalcium Channels, L-Type

Identifiers

PMID23187135
PMCPMC3512169
OpenAlexW1999253291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.