Evidence map›Paper›PMID 23187134›Full record

ArticleThe Journal of clinical investigation2012

Understanding the TXA seizure connection.

Debra A Schwinn, G Burkhard Mackensen, Emery N Brown

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Debra A SchwinnDepartment of Anesthesiology, Pharmacology, and Biochemistry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242-1101, USA. debra-schwinn@uiowa.edu
G Burkhard Mackensen
Emery N Brown

Funding

A Systems Neuroscience Approach for the Study of General AnesthesiaDP1OD003646 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 2007 to 2011
$4.4M
Subcellular Distribution &Regulation of ala-AdrenoceptoR37HL049103 · NHLBI · UNIVERSITY OF WASHINGTON · PI SCHWINN, DEBRA ANNE · 2005 to 2014
$3.9M
MOLECULAR DISTRIBUTION OF HUMAN ADRENERGIC RECEPTORSR01HL049103 · NHLBI · DUKE UNIVERSITY · PI SCHWINN, DEBRA A. · 1993 to 2003
$1.4M
NHLBI NIH HHS HL49103NHLBI NIH HHS R01 HL049103NHLBI NIH HHS R37 HL049103NIH HHS DP1 OD003646NIH HHS DP1OD003646
6 · The paper itself

Abstract

Transexamic acid (TXA) is an antifibrinolytic that has been used successfully to prevent blood loss during major surgery. However, as its usage has increased, there have been growing reports of postsurgical seizure events in cardiac surgery patients. In this issue of the JCI, Lecker et al. explore this connection and suggest that TXA-mediated inhibition of glycine receptors may underlie the effect. This finding prompted the authors to explore the preclinical efficacy of common anesthetics that function by reducing the TXA-mediated inhibition to prevent or modify postsurgical seizures.

Indexed as

AnimalsGABA-A Receptor AntagonistsHumansReceptors, GlycineSeizuresTranexamic AcidGABA-A Receptor AntagonistsReceptors, GlycineTranexamic Acid

Identifiers

PMID23187134
PMCPMC3533567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.