ArticleThe Journal of investigative dermatology2012
Tyrosinase: a central regulatory protein for cutaneous pigmentation.
Article in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 79 citations in OpenAlex.
- Antrodia cinnamomea extract exhibits anti-melanogenic and anti-photoaging effects: potential for cosmetic and dermatological applications.Scientific reports · 2026Article
- Article
- Pigmentation-dependent expression of pheomelanogenesis-related genes in human melanoma cells.Postepy dermatologii i alergologii · 2026Article
- Hydrolyzed conchiolin protein inhibits melanogenesis through PKA/CREB and MEK/ERK signalling pathways.International journal of cosmetic science · 2025Article
- Understanding Mechanisms and Key Factors Influencing Melanogenesis for the Management of Melasma: An Updated Review.Current pharmaceutical biotechnology · 2025Review
- Human Tyrosinase Displayed on the Surface of Chinese Hamster Ovary Cells for Ligand Fishing of Tyrosinase Inhibitors from Medicinal Plants.Molecules (Basel, Switzerland) · 2024Article
- Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery.BMC genomics · 2024Article
- Article
- Dermato-cosmeceutical properties ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution.Frontiers in toxicology · 2023Review
- Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure-activity relationship.Journal of enzyme inhibition and medicinal chemistry · 2022Review
- Experimental study on stromal vascular fraction mediated inhibition of skin pigmentation in guinea pigs.Annals of translational medicine · 2022Article
- Advances in Biomedical Functions of Natural Whitening Substances in the Treatment of Skin Pigmentation Diseases.Pharmaceutics · 2022Review
- Bioactive Phytochemicals ofAntioxidants (Basel, Switzerland) · 2022Article
- Diarylpropionitrile inhibits melanogenesis via protein kinase A/cAMP-response element-binding protein/microphthalmia-associated transcription factor signaling pathway in α-MSH-stimulated B16F10 melanoma cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022Article
- Fraxinol Stimulates Melanogenesis in B16F10 Mouse Melanoma Cells through CREB/MITF Signaling.Molecules (Basel, Switzerland) · 2022Article
- Phytochemical Profiling of the Leaf Extract ofOxidative medicine and cellular longevity · 2022Article
- Isolation of an Extract from the Soft Coral Symbiotic MicroorganismCurrent issues in molecular biology · 2021Article
- Evaluation of Anti-Melanogenesis Activity of EnrichedInternational journal of molecular sciences · 2021Article
- PRP4 Promotes Skin Cancer by Inhibiting Production of Melanin, Blocking Influx of Extracellular Calcium, and Remodeling Cell Actin Cytoskeleton.International journal of molecular sciences · 2021Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous pigmentation or skin color is the body's natural protection against sun-induced damage. Skin color is determined primarily by melanin, a biopolymer that is synthesized within epidermal melanocytes, packaged in cellular organelles called melanosomes, and then dispersed to neighboring keratinocytes. The process of melanogenesis involves numerous molecules and intracellular pathways that are subject to regulation by endogenous and exogenous factors. Tyrosinase is the central and rate-limiting enzyme in melanin biosynthesis. Therefore, elucidation of the molecules and pathways that regulate tyrosinase levels and activity could identify target areas for the development of compounds to decrease excessive pigmentation on one hand or induce pigmentation on the other. The following commentary will summarize the key regulatory molecules and pathways involved in tyrosinase function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.