ArticleNano letters2012
Nanoscale squeezing in elastomeric nanochannels for single chromatin linearization.
Article in Nano letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- The Emergence of Nanofluidics for Single-Biomolecule Manipulation and Sensing.Analytical chemistry · 2025Review
- Internal Motion of Chromatin Fibers Is Governed by Dynamics of Uncompressed Linker Strands.Biophysical journal · 2020Article
- Microfluidic epigenomic mapping technologies for precision medicine.Lab on a chip · 2019Review
- Motor-like DNA motion due to an ATP-hydrolyzing protein under nanoconfinement.Scientific reports · 2018Article
- Electrophoretic stretching and imaging of single native chromatin fibers in nanoslits.Biomicrofluidics · 2017Article
- Dynamic simulations show repeated narrowing maximizes DNA linearization in elastomeric nanochannels.Biomicrofluidics · 2016Article
- The Collapse and Expansion of Liquid-Filled Elastic Channels and Cracks.Journal of applied mechanics · 2015Article
- Arm retraction and escape transition in semi-flexible star polymer under cylindrical confinement.Journal of molecular modeling · 2015Article
- Fracture fabrication of a multi-scale channel device that efficiently captures and linearizes DNA from dilute solutions.Lab on a chip · 2015Article
- Single molecule and single cell epigenomics.Methods (San Diego, Calif.) · 2015Review
- Surface charge, electroosmotic flow and DNA extension in chemically modified thermoplastic nanoslits and nanochannels.The Analyst · 2015Article
- Fracture-based fabrication of normally closed, adjustable, and fully reversible microscale fluidic channels.Small (Weinheim an der Bergstrasse, Germany) · 2014Article
- Elevating sampling.Lab on a chip · 2014Article
- Defined topologically-complex protein matrices to manipulate cell shape via three-dimensional fiber-like patterns.Lab on a chip · 2014Article
- Fracture-based micro- and nanofabrication for biological applications.Biomaterials science · 2014Article
- The Control of Crack Arrays in Thin Films.Journal of materials science · 2014Article
- Guided fracture of films on soft substrates to create micro/nano-feature arrays with controlled periodicity.Scientific reports · 2013Article
- Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics.Nature nanotechnology · 2013Review
- Micro- and nanofluidic technologies for epigenetic profiling.Biomicrofluidics · 2013Article
- Super-resolution imaging of PDMS nanochannels by single-molecule micelle-assisted blink microscopy.The journal of physical chemistry. B · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This paper describes a novel nanofluidic phenomenon where untethered DNA and chromatin are linearized by rapidly narrowing an elastomeric nanochannel filled with solutions of the biopolymers. This nanoscale squeezing procedure generates hydrodynamic flows while also confining the biopolymers into smaller and smaller volumes. The unique features of this technique enable full linearization then trapping of biopolymers such as DNA. The versatility of the method is also demonstrated by analysis of chromatin stretchability and mapping of histone states using single strands of chromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.