ArticleBiochemistry2012
Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent.
Article in Biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Detection to Disruption: A Comprehensive Review of Bacterial Biofilms and Therapeutic Advances.Antibiotics (Basel, Switzerland) · 2026Review
- Two-Component System Sensor Kinase Inhibitors Target the ATP-Lid of PmrB to Disrupt Colistin Resistance inBiochemistry · 2025Article
- Discovery of novel BfmR inhibitors restoring carbapenem susceptibility against carbapenem-resistantEmerging microbes & infections · 2024Article
- Article
- Insights into Kinases of ESKAPE Pathogens for Therapeutic Interventions.Cardiovascular & hematological agents in medicinal chemistry · 2024Review
- Article
- Article
- Non-antibiotic prevention and treatment againstFrontiers in microbiology · 2023Review
- Minocycline and the SPR741 Adjuvant Are an Efficacious Antibacterial Combination forAntibiotics (Basel, Switzerland) · 2022Article
- 2-Aminoimidazoles InhibitInternational journal of molecular sciences · 2022Article
- Article
- Targeting of Regulators as a Promising Approach in the Search for Novel Antimicrobial Agents.Microorganisms · 2022Article
- Factors mediatingCurrent research in microbial sciences · 2022Review
- Phenotypic screening of compound libraries as a platform for the identification of antibiotic adjuvants: Identification of colistin adjuvants from a natural product library.Methods in enzymology · 2022Article
- Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology.Molecules (Basel, Switzerland) · 2021Review
- 2-Aminoimidazole Reduces Fouling and Improves Membrane Performance.Journal of membrane science · 2021Article
- 5-Hydroxymethylfurfural inhibits Acinetobacter baumannii biofilms: an in vitro study.Archives of microbiology · 2021Article
- Natural products as inspiration for the development of bacterial antibiofilm agents.Natural product reports · 2020Review
- PEG-8 Laurate Fermentation ofInternational journal of molecular sciences · 2020Article
- Antimicrobial Resistance in ESKAPE Pathogens.Clinical microbiology reviews · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
2-Aminoimidazoles (2AIs) have been documented to disrupt bacterial protection mechanisms, including biofilm formation and genetically encoded antibiotic resistance traits. Using Acinetobacter baumannii, we provide initial insight into the mechanism of action of a 2AI-based antibiofilm agent. Confocal microscopy confirmed that the 2AI is cell permeable, while pull-down assays identified BfmR, a response regulator that is the master controller of biofilm formation, as a target for this compound. Binding assays demonstrated specificity of the 2AI for response regulators, while computational docking provided models for 2AI-BfmR interactions. The 2AI compound studied here represents a unique small molecule scaffold that targets bacterial response regulators.
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Registered trials
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