ArticleBMC ophthalmology2012
Association analysis of cigarette smoking with onset of primary open-angle glaucoma and glaucoma-related biometric parameters.
Article in BMC ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Tobacco smoking is not associated with primary open-angle glaucoma: a systematic review and meta-analysis.International ophthalmology · 2026Pooled it
- The association between cigarette smoking and primary open-angle glaucoma: a systematic review.International ophthalmology · 2017Pooled it
- A scoping review of advancements in machine learning for glaucoma: current trends and future direction.Frontiers in medicine · 2025Article
- Former smoking as a risk factor for visual field progression in exfoliation glaucoma patients in Sweden.European journal of ophthalmology · 2024Article
- Towards modifying the genetic predisposition for glaucoma: An overview of the contribution and interaction of genetic and environmental factors.Molecular aspects of medicine · 2023Review
- Genetic Associations Between Smoking- and Glaucoma-Related Traits.Translational vision science & technology · 2023Article
- Effect of tobacco smoking on outcomes of trabeculectomy.Arquivos brasileiros de oftalmologia · 2022Article
- The effect of smoking on ocular surface and tear film based on clinical examination and optical coherence tomography.Indian journal of ophthalmology · 2021Article
- Smoking and incidence of glaucoma: The SUN Cohort.Medicine · 2017Article
- Diabetes, Triglyceride Levels, and Other Risk Factors for Glaucoma in the National Health and Nutrition Examination Survey 2005-2008.Investigative ophthalmology & visual science · 2016Article
- Epidemiology and clinical characteristics of patients with glaucoma: An analysis of hospital data between 2003 and 2012.Indian journal of ophthalmology · 2015Article
- Comparison of Risk Factor Profiles for Primary Open-Angle Glaucoma Subtypes Defined by Pattern of Visual Field Loss: A Prospective Study.Investigative ophthalmology & visual science · 2015Article
- Using the bipartite human phenotype network to reveal pleiotropy and epistasis beyond the gene.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2014Article
- Juvenile-onset open-angle glaucoma - A clinical and genetic update.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated cigarette smoking as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT) and intraocular pressure (IOP) in a Chinese cohort.
methodsIn a total of 248 unrelated individuals including 30 juvenile-onset POAG (JOAG), 92 adult-onset POAG (AOAG) and 126 sex-matched senile cataract controls, underwent comprehensive ophthalmic examination. Their smoking was obtained and documented by questionnaire. Association of cigarette smoking with POAG was performed using logistic regression controlled for age and sex. Effects of cigarette smoking on VCDR, IOP and CCT were analyzed with multiple linear regression.
resultsIn either JOAG or AOAG, no association of cigarette smoking was found with disease onset (P = 0.692 and 0.925 respectively). In controls and JOAG, no significant effects of smoking were found on VCDR, IOP or CCT (all P > 0.05). Smoking was found to be correlated with decreased CCT in AOAG and combined POAG (JOAG + AOAG) (P = 0.009 and 0.003), but no association with VCDR or IOP was observed (P > 0.05).
conclusionsAlthough cigarette smoking was not found to be risk factor for onset of POAG, it was correlated with CCT in AOAG, and thus might still play a role in the disease course, especially for AOAG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.