Evidence map›Paper›PMID 23186176›Full record

ArticleBritish journal of pharmacology2013

Sphingosine and the transient receptor potential channel kinase(s).

Tibor Rohacs

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. CaBiomedicines · 2025
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Tibor RohacsUMDNJ-New Jersey Medical School, Newark, NJ 07103, USA. tibor.rohacs@umdnj.edu
Rutgers New Jersey Medical School

Funding

Regulation of sensory TRP channels by phospholipids and G-proteinsR01NS055159 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ROHACS, TIBOR · 2007 to 2022
$5.9M
Regulation of the Intestinal Ca2+ Channels TRPV6R01GM093290 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2011 to 2025
$4.9M
NIGMS NIH HHS R01 GM093290NINDS NIH HHS R01 NS055159
6 · The paper itself

Abstract

Transient receptor potential melastatin 7 (TRPM7) is a multifunctional ion channel playing crucial roles during development. TRPM7 is a member of the highly diverse TRP ion channel family. Most TRP channels are regulated by membrane phospholipids, especially phosphoinositides. In this issue of the British Journal of Pharmacology, Qin et al. describes the regulation of TRPM7 and its close homologue TRPM6 by a different kind of membrane lipid: sphingosine. The study finds that sphingosine is a potent and specific inhibitor of TRPM7 and TRPM6 channels. This commentary briefly summarizes the findings of the study, their potential significance and discusses open question and future directions.

Indexed as

AnimalsFingolimod HydrochlorideHumansMembrane PotentialsMembrane Transport ModulatorsMyocytes, CardiacPropylene GlycolsProtein Kinase InhibitorsProtein Serine-Threonine KinasesSphingosineTRPM Cation ChannelsFingolimod HydrochlorideMembrane Transport ModulatorsPropylene GlycolsProtein Kinase InhibitorsProtein Serine-Threonine KinasesSphingosineTRPM7 protein, humanTRPM Cation Channels

Identifiers

PMID23186176
PMCPMC3596636
OpenAlexW1541649271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.