ArticleDiagnostic pathology2012
Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy.
Article in Diagnostic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.In vivo (Athens, Greece)Pooled it
- Mixed adenoneuroendocrine carcinoma of the gallbladder: a case report and literature review.Frontiers in oncology · 2026Article
- Mixed adenoneuroendocrine carcinoma of the gallbladder: a case report and literature review.Frontiers in oncology · 2025Article
- Does the size of the neuroendocrine-carcinoma component determine the prognosis of gallbladder cancer?Frontiers in endocrinology · 2024Article
- Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review.Diagnostic pathology · 2022Review
- Rare Mixed Adenoneuroendocrine Carcinoma of the Gallbladder: Case Report and Review of Literature.The American journal of case reports · 2021Review
- Neuroendocrine Neoplasms of the Gallbladder: A Clinicopathological Analysis of 13 Patients and a Review of the Literature.Gastroenterology research and practice · 2021Article
- Clinicopathologic and Molecular Features of Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder.Gastroenterology research · 2020Article
- Mixed adenoneuroendocrine carcinoma of the hepatic bile duct: a case report and review of the literature.BMC gastroenterology · 2020Review
- Conversion surgery after extensive chemotherapy for stage IV mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: clinical implications from the patterns of response and recurrence.Clinical journal of gastroenterology · 2020Article
- Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature.Endocrine pathology · 2020Review
- Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review.Clinical journal of gastroenterology · 2020Review
- Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: A Systematic Review of a Controversial and Underestimated Diagnosis.Journal of clinical medicine · 2020Review
- Mixed neuroendocrine-non-neuroendocrine carcinoma of gallbladder: case report.World journal of surgical oncology · 2019Article
- Metastatic mixed adenoneuroendocrine carcinoma of the liver successfully resected by hepatic trisectionectomy following chemotherapy: A case report.Clinical case reports · 2019Article
- Mixed Adeno-Neuroendocrine Carcinoma; Case Series of Ten Patients with Review of the LiteratureBalkan medical journal · 2018Review
- Mixed adenoneuroendocrine carcinoma derived from the cystic duct: A case report.International journal of surgery case reports · 2017Article
- Endocrine cell carcinomas of the colon and rectum: a clinicopathological evaluation.Clinical journal of gastroenterology · 2016Article
- Neuroendocrine liver metastasis in gastric mixed adenoneuroendocrine carcinoma with trilineage cell differentiation: a case report.International journal of clinical and experimental pathology · 2014Article
- Mixed adeno(neuro)endocrine carcinoma arising from the ectopic gastric mucosa of the upper thoracic esophagus.World journal of surgical oncology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixed adenoneuroendocrine carcinoma (MANEC) carcinomas rarely occur in the gallbladder. Here we reported a case of giant gallbladder unresectable mass with local liver invasion and omentum metastasis, which proved to be neuroendocrine carcinoma (NEC) by biopsy, received successful radical operation after neo-adjuvant chemotherapy plus somatostatin treatment. The patient showed good response as the neoplasm diminished dramatically and showed clear margin after 6 courses of treatment. A radical operation including cholecystectomy, hepatic wedge resection of the gallbladder fossa segment and lymph node of group 8a and 8p resection was performed successfully. Postoperative histopathological examination revealed neuroendocrine carcinoma mixed with adenocarcinoma in the gallbladder wall. Followed up showed no evidence of recurrence after 7 months of the operation. We suggest that neo-adjuvant chemotherapy may be beneficial to gallbladder mixed neuroendocrine carcinomas in an advanced stage which could also be advantageous to NEC of other organs. VIRTUAL SLIDES: http://www.diagnosticpathology.diagnomx.eu/vs/2731892837743787.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.