ArticleTherapeutic advances in endocrinology and metabolism2012
Diabetes treatment in 2025: can scientific advances keep pace with prevalence?
Article in Therapeutic advances in endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Isolated bovine pancreatic islets as an alternate in vitro model for diabetes research.The Indian journal of medical research · 2024Article
- Hydrogel-based Drug Delivery System in Diabetes Management.Pharmaceutical nanotechnology · 2024Review
- Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches.BMJ open diabetes research & care · 2021Article
- The use of metformin as an add-on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescents.Metabolism open · 2021Article
- Therapeutic potential of mesenchymal stem cells in treating both types of diabetes mellitus and associated diseases.Journal of diabetes and metabolic disorders · 2020Review
- Effects of Biotin Supplementation During the First Week Postweaning Increases Pancreatic Islet Area, Beta-Cell Proportion, Islets Number, and Beta-Cell Proliferation.Journal of medicinal food · 2018Article
- Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.Cell death & disease · 2017Article
- Implications of Resveratrol on Glucose Uptake and Metabolism.Molecules (Basel, Switzerland) · 2017Review
- Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Review
- The role of air pollutants in initiating liver disease.Toxicological research · 2014Review
- The role of bariatric surgery in the treatment of type 2 diabetes: current evidence and clinical guidelines.Current atherosclerosis reports · 2013Review
- Exposure to ambient air particulate matter and non-alcoholic fatty liver disease.World journal of gastroenterology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the known benefits of a healthy lifestyle, many individuals find it hard to maintain such a lifestyle in our modern world, which facilitates sedentary behavior and overeating. As a consequence, the prevalence of type 2 diabetes mellitus is predicted to increase dramatically over the coming years. Will developments in treatments be able to counteract the resulting impact on morbidity and mortality? The various lines of research can be grouped into three main categories: technological, biological, and pharmacological. Technological solutions are focused on the delivery of insulin and glucagon via an artificial pancreas, and components of the system are already in use, suggesting this option may well be available within the next 10 years. Of the biological solutions, pancreas transplants seem unlikely to be used widely, and islet cell transplants have also been hampered by a lack of appropriate donor tissue and graft survival after transplant. However, significant progress has been made in these areas, and additional research suggests manipulating other cell types to replace beta cells may be a viable option in the longer term. The last category, pharmacological research, appears the most promising for significantly reducing the burden of type 2 diabetes mellitus. In recent years, research has concentrated on reducing blood glucose, and the increasing pace of research has been reflected in a growing number of antidiabetic agents. In the past few years, studies of the complementary approach of protecting cells from the damaging effects of high blood glucose have also been reported, as has research into the control of energy intake and energy expenditure. Evidence from studies of dietary restriction and bariatric surgery suggests it may be possible to reset metabolism to effectively cure diabetes, and research into pharmacological agents that could selectively restore energy balance is currently the most exciting prospect for future treatments for people with type 2 diabetes mellitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.