ArticlePloS one2012
Separation of fNIRS signals into functional and systemic components based on differences in hemodynamic modalities.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of the Application of Functional Near-Infrared Spectroscopy to the Study of Cerebral Hemodynamics in Healthy Aging.Neuropsychology review · 2021Pooled it
- Modulation of prefrontal functional connectivity by tDCS over the left DLPFC predicts performance enhancement in swimmers: a simultaneous tDCS-fNIRS, double-blind, sham-controlled crossover study.European journal of applied physiology · 2026Trial
- Resting-state hemodynamic changes and effects on upper limb function after multi-channel transcranial direct current stimulation to the ipsilesional primary motor cortex and anterior intraparietal sulcus in stroke patients: an fNIRS pilot study.Journal of neuroengineering and rehabilitation · 2025Trial
- Effects of the characteristic temperament of cats on the emotions and hemodynamic responses of humans.PloS one · 2020Trial
- Emergent blink rate in early childhood is associated with neural origins of executive function.Communications psychology · 2026Article
- Machine Learning Classification of Migraine Using fNIRS During a Postural Task.Brain sciences · 2026Article
- NIRSLINK: A Modular Cascaded Wearable Near-Infrared Spectroscopy System for High-Speed Multi-Site Hemodynamic Monitoring.Biosensors · 2026Article
- Enhancement of Cerebral Oxygenation by Lower-Limb Neuromuscular Electrical Stimulation in Stroke Survivors.Annals of biomedical engineering · 2026Observational
- Brain network characteristics and behavioral correlations in global developmental delay based on functional near-infrared spectroscopy.iScience · 2026Article
- Executive function and language: a behavioural and functional near-infrared spectroscopy study in 23 normally hearing children and one deaf child with cochlear implants.Frontiers in human neuroscience · 2026Review
- Article
- Optimizing short-channel regression in fNIRS: an empirical evaluation with ecological audiovisual stimuli.Neurophotonics · 2026Article
- Prefrontal Cortex Oxygenation Dynamics During Walking in Patients with Acute Stroke.Advances in experimental medicine and biology · 2026Article
- Prefrontal cortex oxygenation dynamics during dual-task walking in independently ambulatory patients with acute stroke: a comparison with healthy older adults.Frontiers in human neuroscience · 2026Article
- Evaluation of human body malodor using functional near-infrared spectroscopy with regions of interest based on functional pathways in the olfactory system.Frontiers in neuroscience · 2026Article
- How to design real-world functional near-infrared spectroscopy studies: a primer.Neurophotonics · 2026Article
- Acute 3.5-minute light-intensity exercise enhances executive function and psychological mood in children.Scientific reports · 2025Article
- Cortical Representation of Auditory Selective Attention in a Dichotic Listening Task: A Functional Near-Infrared Spectroscopy Study.Brain topography · 2025Article
- Distinct Roles of the Premotor and Occipitotemporal Cortices in the Full-Body Illusion.eNeuro · 2025Article
- Aberrant neural activation during inhibitory control in girls with fragile X syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In conventional functional near-infrared spectroscopy (fNIRS), systemic physiological fluctuations evoked by a body's motion and psychophysiological changes often contaminate fNIRS signals. We propose a novel method for separating functional and systemic signals based on their hemodynamic differences. Considering their physiological origins, we assumed a negative and positive linear relationship between oxy- and deoxyhemoglobin changes of functional and systemic signals, respectively. Their coefficients are determined by an empirical procedure. The proposed method was compared to conventional and multi-distance NIRS. The results were as follows: (1) Nonfunctional tasks evoked substantial oxyhemoglobin changes, and comparatively smaller deoxyhemoglobin changes, in the same direction by conventional NIRS. The systemic components estimated by the proposed method were similar to the above finding. The estimated functional components were very small. (2) During finger-tapping tasks, laterality in the functional component was more distinctive using our proposed method than that by conventional fNIRS. The systemic component indicated task-evoked changes, regardless of the finger used to perform the task. (3) For all tasks, the functional components were highly coincident with signals estimated by multi-distance NIRS. These results strongly suggest that the functional component obtained by the proposed method originates in the cerebral cortical layer. We believe that the proposed method could improve the reliability of fNIRS measurements without any modification in commercially available instruments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.