ArticlePloS one2012
Influence of architecture of β-tricalcium phosphate scaffolds on biological performance in repairing segmental bone defects.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- An ingenious design from nature to accelerate the repair of long-bone critical defects: the longitudinal tubular transverse interconnection structure of deer antlers.Materials today. Bio · 2025Article
- Treatment of large bone defects in load-bearing bone: traditional and novel bone grafts.Journal of Zhejiang University. Science. B · 2025Review
- NOVEL HIGH-STRENGTH POLYESTER COMPOSITE SCAFFOLDS FOR BONE REGENERATION.Polymers for advanced technologies · 2023Article
- Effects of Channels and Micropores in Honeycomb Scaffolds on the Reconstruction of Segmental Bone Defects.Frontiers in bioengineering and biotechnology · 2022Article
- The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits.PloS one · 2020Article
- Reconsidering Osteoconduction in the Era of Additive Manufacturing.Tissue engineering. Part B, Reviews · 2019Review
- An Innovative Approach for Enhancing Bone Defect Healing Using PLGA Scaffolds Seeded with Extracorporeal-shock-wave-treated Bone Marrow Mesenchymal Stem Cells (BMSCs).Scientific reports · 2017Article
- In Vitro and In Vivo Dentinogenic Efficacy of Human Dental Pulp-Derived Cells Induced by Demineralized Dentin Matrix and HA-TCP.Stem cells international · 2017Article
- Article
- Geometry Design Optimization of Functionally Graded Scaffolds for Bone Tissue Engineering: A Mechanobiological Approach.PloS one · 2016Article
- A Mechanobiology-based Algorithm to Optimize the Microstructure Geometry of Bone Tissue Scaffolds.International journal of biological sciences · 2016Article
- Bone substitutes and implantation depths for subchondral bone repair in osteochondral defects of porcine knee joints.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough three-dimensional (3D) β-tricalcium phosphate (β-TCP) scaffolds serve as promising bone graft substitutes for the segmental bone defect treatment, no consensus has been achieved regarding their optimal 3D architecture.
methodsIn this study, we has systematically compared four types of β-TCP bone graft substitutes with different 3D architectures, including two types of porous scaffolds, one type of tubular scaffolds and one type of solid scaffolds, for their efficacy in treating segmental bone defect in a rabbit model.
resultsOur study has demonstrated that when compared to the traditional porous and solid scaffolds, tubular scaffolds promoted significantly higher amount of new bone formation in the defect regions as shown by X-ray, micro CT examinations and histological analysis, restored much greater mechanical properties of the damaged bone evidenced by the biomechanical testing, and eventually achieved the complete union of segmental defect. Moreover, the implantation of tubular scaffolds enhanced the neo-vascularization at the defect region with higher bone metabolic activities than others, as indicated by the bone scintigraphy assay.
conclusionsThis study has further the current knowledge regarding the profound influence of overall 3D architecture of β-TCP scaffolds on their in vivo defect healing performance and illuminated the promising potential use of tubular scaffolds as effective bone graft substitute in treating large segmental bone defects.
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