ArticlePloS one2012
Substrate-specific gene expression in Batrachochytrium dendrobatidis, the chytrid pathogen of amphibians.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- Amphibians After Disease-Induced Declines: Genetic Insights Into Population Recoveries.Molecular ecology · 2026Article
- Using fluorescent in vitro amphibian cell infection models to quantify pathogenicity of Batrachochytrium dendrobatidis.Methods (San Diego, Calif.) · 2026Article
- Infectivity of amphibian chytrid fungi requires metalloprotease-driven spore development and germ tube formation.BMC microbiology · 2026Article
- Investigating the potential neurotoxic effects of cell-free factors by Batrachochytrium dendrobatidis on locomotion in Xenopus laevis.Biology open · 2026Article
- Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi.Molecular biology of the cell · 2025Article
- Comparative Genomics Reveals Intra and Inter Species Variation in the Pathogenic Fungus Batrachochytrium dendrobatidis.Genome biology and evolution · 2025Article
- In Vitro Infection Model Using A6 Cells Sets the Stage for Host-Journal of fungi (Basel, Switzerland) · 2025Article
- Conserved Evolution of MHC Supertypes among Japanese Frogs Suggests Selection for Bd Resistance.Animals : an open access journal from MDPI · 2023Article
- Immune priming prior to pathogen exposure sheds light on the relationship between host, microbiome and pathogen in disease.Royal Society open science · 2023Article
- In Silico Predictions of Ecological Plasticity Mediated by Protein Family Expansions in Early-Diverging Fungi.Journal of fungi (Basel, Switzerland) · 2022Article
- Chytridiomycosis in Asian Amphibians, a Global Resource forJournal of the Indian Institute of Science · 2021Review
- Review
- Experimental methodologies can affect pathogenicity of Batrachochytrium salamandrivorans infections.PloS one · 2020Article
- Infection mechanisms and putative effector repertoire of the mosquito pathogenic oomycete Pythium guiyangense uncovered by genomic analysis.PLoS genetics · 2019Article
- Phenotypic Divergence along Geographic Gradients Reveals Potential for Rapid Adaptation of the White-Nose Syndrome Pathogen, Pseudogymnoascus destructans, in North America.Applied and environmental microbiology · 2018Article
- Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation including profound failure of cellular energy pathways.Scientific reports · 2018Article
- Development and worldwide use of non-lethal, and minimal population-level impact, protocols for the isolation of amphibian chytrid fungi.Scientific reports · 2018Article
- What We Do Not Know about Fungal Cell Adhesion Molecules.Journal of fungi (Basel, Switzerland) · 2018Review
- First in Vivo Batrachochytrium dendrobatidis Transcriptomes Reveal Mechanisms of Host Exploitation, Host-Specific Gene Expression, and Expressed Genotype Shifts.G3 (Bethesda, Md.) · 2017Article
- Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Determining the mechanisms of host-pathogen interaction is critical for understanding and mitigating infectious disease. Mechanisms of fungal pathogenicity are of particular interest given the recent outbreaks of fungal diseases in wildlife populations. Our study focuses on Batrachochytrium dendrobatidis (Bd), the chytrid pathogen responsible for amphibian declines around the world. Previous studies have hypothesized a role for several specific families of secreted proteases as pathogenicity factors in Bd, but the expression of these genes has only been evaluated in laboratory growth conditions. Here we conduct a genome-wide study of Bd gene expression under two different nutrient conditions. We compare Bd gene expression profiles in standard laboratory growth media and in pulverized host tissue (i.e., frog skin). A large proportion of genes in the Bd genome show increased expression when grown in host tissue, indicating the importance of studying pathogens on host substrate. A number of gene classes show particularly high levels of expression in host tissue, including three families of secreted proteases (metallo-, serine- and aspartyl-proteases), adhesion genes, lipase-3 encoding genes, and a group of phylogenetically unusual crinkler-like effectors. We discuss the roles of these different genes as putative pathogenicity factors and discuss what they can teach us about Bd's metabolic targets, host invasion, and pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.