ArticlePloS one2012
A novel function for SNAP29 (synaptosomal-associated protein of 29 kDa) in mast cell phagocytosis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Detection of Mast Cells and Basophils by Immunohistochemistry.Methods in molecular biology (Clifton, N.J.) · 2020Article
- SNARE-Mediated Exocytosis in Neuronal Development.Frontiers in molecular neuroscience · 2020Review
- In the line-up: deleted genes associated with DiGeorge/22q11.2 deletion syndrome: are they all suspects?Journal of neurodevelopmental disorders · 2019Review
- Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.Nature communications · 2018Article
- Functional diversification of the NleG effector family in enterohemorrhagicProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Review
- Role of Mast Cells in clearance of Leishmania through extracellular trap formation.Scientific reports · 2017Article
- An essential step of kinetochore formation controlled by the SNARE protein Snap29.The EMBO journal · 2016Article
- Roles and relevance of mast cells in infection and vaccination.Journal of biomedical research · 2016Review
- Article
- Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks.PloS one · 2015Article
- Escherichia coli exposure inhibits exocytic SNARE-mediated membrane fusion in mast cells.Traffic (Copenhagen, Denmark) · 2014Article
- Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila.Autophagy · 2014Article
- Drosophila SNAP-29 is an essential SNARE that binds multiple proteins involved in membrane traffic.PloS one · 2014Article
- A genome-wide association study for somatic cell score using the Illumina high-density bovine beadchip identifies several novel QTL potentially related to mastitis susceptibility.Frontiers in genetics · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mast cells play a critical role in the innate immune response to bacterial infection. They internalize and kill a variety of bacteria and process antigen for presentation to T cells via MHC molecules. Although mast cell phagocytosis appears to play a significant role during bacterial infection, little is known about the proteins involved in its regulation. In this study, we demonstrate that the SNARE protein SNAP29 is involved in mast cell phagocytosis. SNAP29 is localized in the endocytic pathway and is transiently recruited to Escherichia coli (E. coli)-containing phagosomes. Interestingly, overexpression of SNAP29 significantly increases the internalization and killing of E. coli, while it does not affect mast cell exocytosis of inflammatory mediators. To our knowledge, these data are the first to demonstrate a novel function of SNAP29 in mast cell phagocytosis and have implications in protection against bacterial infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.