ArticlePloS one2012
Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
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- Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs inFrontiers in molecular neuroscience · 2023Article
- The antennal transcriptome of Triatoma infestans reveals substantial expression changes triggered by a blood meal.BMC genomics · 2022Article
- Identification of an arthropod molecular target for plant-derived natural repellents.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nutrient Sensing via Gut inInternational journal of molecular sciences · 2022Review
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- Transcriptome profiles of Anopheles gambiae harboring natural low-level Plasmodium infection reveal adaptive advantages for the mosquito.Scientific reports · 2021Article
- Behavioral and Genomic Sensory Adaptations Underlying the Pest Activity of Drosophila suzukii.Molecular biology and evolution · 2021Article
- Review
- Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus.BMC genomics · 2020Article
- A Functional Agonist of Insect Olfactory Receptors: Behavior, Physiology and Structure.Frontiers in cellular neuroscience · 2019Article
- Evaluation of reference genes for insect olfaction studies.Parasites & vectors · 2015Article
- An RNA-seq screen of the Drosophila antenna identifies a transporter necessary for ammonia detection.PLoS genetics · 2014Article
- Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies.Handbook of experimental pharmacology · 2014Article
- Olfactory carbon dioxide detection by insects and other animals.Molecules and cells · 2013Review
- Molecular Principles of Insect Chemoreception.Acta naturaeArticle
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMembers of the canonical Transient Receptor Potential (TRPC) class of cationic channels function downstream of Gαq and PLCβ in Drosophila photoreceptors for transducing visual stimuli. Gαq has recently been implicated in olfactory sensing of carbon dioxide (CO(2)) and other odorants. Here we investigated the role of PLCβ and TRPC channels for sensing CO(2) in Drosophila. METHODOLOGY/PRINCIPAL
findingsThrough behavioral assays it was demonstrated that Drosophila mutants for plc21c, trp and trpl have a reduced sensitivity for CO(2). Immuno-histochemical staining for TRP, TRPL and TRPγ indicates that all three channels are expressed in Drosophila antennae including the sensory neurons that express CO(2) receptors. Electrophysiological recordings obtained from the antennae of protein null alleles of TRP (trp(343)) and TRPL (trpl(302)), showed that the sensory response to multiple concentrations of CO(2) was reduced. However, trpl(302); trp(343) double mutants still have a residual response to CO(2). Down-regulation of TRPC channels specifically in CO(2) sensing olfactory neurons reduced the response to CO(2) and this reduction was obtained even upon down-regulation of the TRPCs in adult olfactory sensory neurons. Thus the reduced response to CO(2) obtained from the antennae of TRPC RNAi strains is not due to a developmental defect.
conclusionThese observations show that reduction in TRPC channel function significantly reduces the sensitivity of the olfactory response to CO(2) concentrations of 5% or less in adult Drosophila. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Gαq and PLC21C.
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