ArticlePloS one2012
Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Current evidence on the use of anti-RAAS agents in congenital or acquired solitary kidney.Renal failure · 2017Pooled it
- Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep.Clinical science (London, England : 1979) · 2025Article
- The Kidney-Gut Axis as a Novel Target for Nutritional Intervention to Counteract Chronic Kidney Disease Progression.Metabolites · 2024Review
- Glomerular hyperfiltration: part 2-clinical significance in children.Pediatric nephrology (Berlin, Germany) · 2023Review
- Prevalence of reflux nephropathy in Iranian children with solitary kidney: results of a multi-center study.BMC nephrology · 2022Article
- Image analysis techniques to map pyramids, pyramid structure, glomerular distribution, and pathology in the intact human kidney from 3-D MRI.American journal of physiology. Renal physiology · 2021Article
- Renal growth slope in children with congenital and acquired solitary functioning kidneys.Ultrasonography (Seoul, Korea) · 2021Article
- [Long-term analysis of safety and efficacy of standard percutaneous nephrolithotomy in patients with solitary kidneys].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- Physiology and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney.Frontiers in physiology · 2020Review
- Towards adulthood with a solitary kidney.Pediatric nephrology (Berlin, Germany) · 2019Review
- Evolutionary Nephrology.Kidney international reports · 2017Article
- Nephron number, hypertension, and CKD: physiological and genetic insight from humans and animal models.Physiological genomics · 2017Review
- Nephron Deficiency and Predisposition to Renal Injury in a Novel One-Kidney Genetic Model.Journal of the American Society of Nephrology : JASN · 2015Article
- Clinical implications of the solitary functioning kidney.Clinical journal of the American Society of Nephrology : CJASN · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with unilateral MultiCystic Kidney Dysplasia (MCKD) or unilateral renal agenesis (URA) have a congenital solitary functioning kidney (CSFK) that is compensatory enlarged. The question whether this enlargement is due to increased nephron numbers and/or to nephron hypertrophy is unresolved. This question is of utmost clinical importance, since hypertrophy is associated with a risk of developing hypertension and proteinuria later in life with consequent development of CKD and cardiovascular disease. METHODOLOGY/PRINCIPAL
findingsIn a cohort of 32,000 slaughter pigs, 7 congenital solitary functioning kidneys and 7 control kidneys were identified and harvested. Cortex volume was measured and with a 3-dimensional stereologic technique the number and volume of glomeruli was determined and compared. The mean total cortex volume was increased by more than 80% and the mean number of glomeruli per kidney was 50% higher in CSFKs than in a single control kidney, equaling 75% of the total nephron number in both kidneys of control subjects. The mean total glomerular volume in the CSFKs was not increased relative to the controls. CONCLUSIONS/SIGNIFICANCE: Thus, in pigs, compensatory enlargement of a CSFK is based on increased nephron numbers. Extrapolation of these findings to the human situation suggests that patients with a CSFK might not be at increased risk for developing hyperfiltration-associated renal and cardiovascular disease in later life due to a lower nephron number.
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