ArticlePloS one2012
Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: findings from the LIFE-P study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Effect of Intensive Blood Pressure Control on Gait Speed and Mobility Limitation in Adults 75 Years or Older: A Randomized Clinical Trial.JAMA internal medicine · 2017Trial
- The association between estimated pulse wave velocity and balance function in U.S. adults.Journal of human hypertension · 2025Article
- Declined intrinsic capacity is associated with one-year functional disability in older hypertensive inpatients.BMC geriatrics · 2025Observational
- Physical performance changes as clues to late-life blood pressure changes with advanced age: the osteoporotic fractures in men study.The journal of nutrition, health & aging · 2024Article
- Association of Vascular Health Measures and Physical Function: A Prospective Analysis in the Framingham Heart Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Arterial stiffness and augmentation index are associated with balance function in young adults.European journal of applied physiology · 2023Article
- The Associations of Pulse Pressure and Mean Arterial Pressure on Physical Function in Older Americans.Geriatrics (Basel, Switzerland) · 2023Article
- Increased cardiovascular stiffness and impaired age-related functional status.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Article
- Longitudinal physical performance and blood pressure changes in older women: Findings form the women's health initiative.Archives of gerontology and geriatricsArticle
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Authors and funding
11 authors.
Funding
Abstract
backgroundReduced gait speed is associated with falls, late-life disability, hospitalization/institutionalization and cardiovascular morbidity and mortality. Aging is also accompanied by a widening of pulse pressure (PP) that contributes to ventricular-vascular uncoupling. The purpose of this study was to test the hypothesis that PP is associated with long-distance gait speed in community-dwelling older adults in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study.
methodsBrachial blood pressure and 400-meter gait speed (average speed maintained over a 400-meter walk at "usual" pace) were assessed in 424 older adults between the ages of 70-89 yrs at risk for mobility disability (mean age=77 yrs; 31% male). PP was calculated as systolic blood pressure (BP) - diastolic BP.
resultsPatients with a history of heart failure and stroke (n=42) were excluded leaving 382 participants for final analysis. When categorized into tertiles of PP, participants within the highest PP tertile had significantly slower gait speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip strength, body weight, age and history of diabetes mellitus (p<0.05). Mean arterial pressure, systolic BP and diastolic BP were not predictors of gait speed.
conclusionsPulse pressure is associated long-distance gait speed in community-dwelling older adults. Vascular senescence and altered ventricular-vascular coupling may be associated with the deterioration of mobility and physical function in older adults.
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