ArticlePloS one2012
Dietary restriction during development enlarges intestinal and hypodermal lipid droplets in Caenorhabditis elegans.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Lysergic acid diethylamide extends lifespan in Caenorhabditis elegans.Biogerontology · 2026Article
- Basal cytoplasmic calcium levels regulate C. elegans germ stem cell proliferation.Development (Cambridge, England) · 2026Article
- Basal cytoplasmic calcium levels regulatebioRxiv : the preprint server for biology · 2025Article
- Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans.Nature communications · 2024Article
- An antisteatosis response regulated by oleic acid through lipid droplet-mediated ERAD enhancement.Science advances · 2023Article
- Drosophila Sirtuin 6 mediates developmental diet-dependent programming of adult physiology and survival.Aging cell · 2022Article
- Lamin regulates the dietary restriction response via the mTOR pathway in Caenorhabditis elegans.Journal of cell science · 2021Article
- Friend or Foe: Lipid Droplets as Organelles for Protein and Lipid Storage in Cellular Stress Response, Aging and Disease.Molecules (Basel, Switzerland) · 2020Review
- Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes.Developmental cell · 2019Article
- Dietary restriction induces posttranscriptional regulation of longevity genes.Life science alliance · 2019Article
- Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans.Lab on a chip · 2018Article
- Caloric restriction promotes functional changes involving short-chain fatty acid biosynthesis in the rat gut microbiota.Scientific reports · 2018Article
- Biosynthetic tailoring of existing ascaroside pheromones alters their biological function ineLife · 2018Article
- Lipid and Carbohydrate Metabolism inGenetics · 2017Review
- The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans.The Journal of biological chemistry · 2017Article
- Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Octopamine connects nutrient cues to lipid metabolism upon nutrient deprivation.Science advances · 2016Article
- An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast.PLoS genetics · 2016Article
- Methyl group donors abrogate adaptive responses to dietary restriction in C. elegans.Genes & nutrition · 2016Article
- Metabolome and proteome changes with aging in Caenorhabditis elegans.Experimental gerontology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary restriction (DR) extends lifespan in man species and modulates evolutionary conserved signalling and metabolic pathways. Most of these studies were done in adult animals. Here we investigated fat phenotypes of C. elegans larvae and adults which were exposed to DR during development. This approach was named "developmental-DR" (dDR). Moderate as well as stringent dDR increased the triglyceride to protein ratio in L4 larvae and adult worms. This alteration was accompanied by a marked expansion of intestinal and hypodermal lipid droplets. In comparison to ad libitum condition, the relative proportion of fat stored in large lipid droplets (>50 µm(3)) was increased by a factor of about 5 to 6 in larvae exposed to dDR. Microarray-based expression profiling identified several dDR-regulated genes of lipolysis and lipogenesis which may contribute to the observed fat phenotypes. In conclusion, dDR increases the triglyceride to protein ratio, enlarges lipid droplets and alters the expression of genes functioning in lipid metabolism in C. elegans. These changes might be an effective adaptation to conserve fat stores in animals subjected to limiting food supply during development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.