ArticleArchives of medical science : AMS2012
Coffee consumption and risk of fractures: a meta-analysis.
Article in Archives of medical science : AMS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Impact of Lockdowns on Caffeine Consumption: A Systematic Review of the Evidence.International journal of environmental research and public health · 2022Pooled it
- Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes.BMJ (Clinical research ed.) · 2017Pooled it
- Effect of coffee intake on hip fracture: a meta-analysis of prospective cohort studies.Nutrition journal · 2015Pooled it
- Coffee, tea, and the risk of hip fracture: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Pooled it
- Yerba Mate and Bone Health: Can Antioxidant Capacity Influence Skeletal Outcomes?Journal of bone metabolism · 2026Article
- Positive Effect of Yerba Mate (Ilex paraguariensis) Consumption on Bone Mineral Density in Postmenopausal Women Assessed by Dual Energy X-Ray Absorptiometry-Based 3-Dimensional Modeling.Journal of bone metabolism · 2025Article
- Increased Osteoblastic and Osteocytic in Vitro Cell Viability by Yerba Mate (Ilex paraguariensis).Journal of bone metabolism · 2024Article
- The association between caffeine intake and testosterone: NHANES 2013-2014.Nutrition journal · 2022Article
- The importance of the circadian system & sleep for bone health.Metabolism: clinical and experimental · 2018Review
- Caffeine at a Moderate Dose Did Not Affect the Skeletal System of Rats with Streptozotocin-Induced Diabetes.Nutrients · 2017Article
- Subjective evaluation of the frequency of coffee intake and relationship to osteoporosis in Chinese men.Journal of health, population, and nutrition · 2016Article
- Optimization of roasting conditions through antioxidant and anti-inflammatory activities ofFood science and biotechnology · 2016Article
- Associations between frequency of coffee consumption and osteoporosis in Chinese postmenopausal women.International journal of clinical and experimental medicine · 2015Article
- Article
- Phenotype refinement strengthens the association of AHR and CYP1A1 genotype with caffeine consumption.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecent studies have indicated higher risk of fractures among coffee drinkers. To quantitatively assess the association between coffee consumption and the risk of fractures, we conducted this meta-analysis. MATERIAL AND
methodsWe searched MEDLINE and EMBASE for prospective studies reporting the risk of fractures with coffee consumption. Quality of included studies was assessed with the Newcastle Ottawa scale. We conducted a meta-analysis and a cumulative meta-analysis of relative risk (RR) for an increment of one cup of coffee per day, and explored the potential dose-response relationship. Sensitivity analysis was performed where statistical heterogeneity existed.
resultsWe included 10 prospective studies covering 214,059 participants and 9,597 cases. There was overall 3.5% higher fracture risk for an increment of one cup of coffee per day (RR = 1.035, 95% CI: 1.019-1.052). Pooled RRs were 1.049 (95% CI: 1.022-1.077) for women and 0.910 (95% CI: 0.873-0.949) for men. Among women, RR was 1.055 (95% CI: 0.999-1.114) for younger participants, and 1.047 (95% CI: 1.016-1.080) for older ones. Cumulative meta-analysis indicated that risk estimates reached a stabilization level (RR = 1.035, 95% CI: 1.019-1.052), and it revealed a positive dose-response relationship between coffee consumption and risk of fractures either for men and women combined or women specifically.
conclusionsThis meta-analysis suggests an overall harm of coffee intake in increasing the risk of fractures, especially for women. But current data are insufficient to reach a convincing conclusion and further research needs to be conducted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.