ArticleJournal of applied biomechanics2013
Effects of age-related differences in femoral loading and bone mineral density on strains in the proximal femur during controlled walking.
Article in Journal of applied biomechanics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed.
- Effects of Aging on Osteosynthesis at Bone-Implant Interfaces.Biomolecules · 2023Review
- Bone mineral density and its relationship with ground reaction force characteristics during gait in young adults with Prader-Willi Syndrome.Bone reports · 2023Article
- Effect of gait types and external weight carrying strategies on the femoral neck strains during stair descent.PloS one · 2023Article
- A Comparative Study on the Multiscale Mechanical Responses of Human Femoral Neck Between the Young and the Elderly Using Finite Element Method.Frontiers in bioengineering and biotechnology · 2022Article
- Finite element analysis of femoral neck strains during stair ascent and descent.Scientific reports · 2021Article
- Measuring femoral neck loads in healthy young and older adults during stair ascent and descent.PloS one · 2021Article
- Reengineering Bone-Implant Interfaces for Improved Mechanotransduction and Clinical Outcomes.Stem cell reviews and reports · 2020Review
- Modelling Human Locomotion to Inform Exercise Prescription for Osteoporosis.Current osteoporosis reports · 2020Review
- Optimizing Accuracy of Proximal Femur Elastic Modulus Equations.Annals of biomedical engineering · 2019Article
- Ranking of osteogenic potential of physical exercises in postmenopausal women based on femoral neck strains.PloS one · 2018Article
- Comparison of microstructural and mechanical properties of trabeculae in femoral head from osteoporosis patients with and without cartilage lesions: a case-control study.BMC musculoskeletal disorders · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Maintenance of healthy bone mineral density (BMD) is important for preventing fractures in older adults. Strains experienced by bone in vivo stimulate remodeling processes, which can increase or decrease BMD. However, there has been little study of age differences in bone strains. This study examined the relative contributions of age-related differences in femoral loading and BMD to age-related differences in femoral strains during walking using gait analysis, static optimization, and finite element modeling. Strains in older adult models were similar or larger than in young adult models. Reduced BMD increased strains in a fairly uniform manner, whereas older adult loading increased strains in early stance but decreased strains in late stance. Peak ground reaction forces, hip joint contact forces, and hip flexor forces were lower in older adults in late stance phase, and this helped older adults maintain strains similar to those of young adults despite lower BMD. Because walking likely represents a "baseline" level of stimulus for bone remodeling processes, increased strains during walking in older adults might indicate the extent of age-related impairment in bone remodeling processes. Such a measure might be clinically useful if it could be accurately determined with age-appropriate patient-specific loading, geometry, and BMD.
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Registered trials
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