ArticleNucleic acids research2013
ChemProt-2.0: visual navigation in a disease chemical biology database.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A computational approach to chemical etiologies of diabetes.Scientific reports · 2013Pooled it
- Large language models for bioinformatics.Quantitative biology (Beijing, China) · 2026Review
- Network Pharmacology Approach for Medicinal Plants: Review and Assessment.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Machine learning approaches and databases for prediction of drug-target interaction: a survey paper.Briefings in bioinformatics · 2021Review
- Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.Environmental health perspectives · 2019Article
- Article
- A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission.Toxicology and applied pharmacology · 2018Article
- Predicting the Reliability of Drug-target Interaction Predictions with Maximum Coverage of Target Space.Scientific reports · 2017Article
- The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands.Nucleic acids research · 2016Article
- STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data.Nucleic acids research · 2016Article
- ChemProt-3.0: a global chemical biology diseases mapping.Database : the journal of biological databases and curation · 2016Article
- Activity, assay and target data curation and quality in the ChEMBL database.Journal of computer-aided molecular design · 2015Article
- PhIN: A Protein Pharmacology Interaction Network Database.CPT: pharmacometrics & systems pharmacology · 2015Article
- ChemDIS: a chemical-disease inference system based on chemical-protein interactions.Journal of cheminformatics · 2015Article
- Using VisANT to Analyze Networks.Current protocols in bioinformatics · 2014Article
- Identification of odorant-receptor interactions by global mapping of the human odorome.PloS one · 2014Article
- VisANT 4.0: Integrative network platform to connect genes, drugs, diseases and therapies.Nucleic acids research · 2013Article
- Predicting the protein targets for athletic performance-enhancing substances.Journal of cheminformatics · 2013Article
- The CARLSBAD database: a confederated database of chemical bioactivities.Database : the journal of biological databases and curation · 2013Article
- Navigating traditional chinese medicine network pharmacology and computational tools.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
ChemProt-2.0 (http://www.cbs.dtu.dk/services/ChemProt-2.0) is a public available compilation of multiple chemical-protein annotation resources integrated with diseases and clinical outcomes information. The database has been updated to >1.15 million compounds with 5.32 millions bioactivity measurements for 15 290 proteins. Each protein is linked to quality-scored human protein-protein interactions data based on more than half a million interactions, for studying diseases and biological outcomes (diseases, pathways and GO terms) through protein complexes. In ChemProt-2.0, therapeutic effects as well as adverse drug reactions have been integrated allowing for suggesting proteins associated to clinical outcomes. New chemical structure fingerprints were computed based on the similarity ensemble approach. Protein sequence similarity search was also integrated to evaluate the promiscuity of proteins, which can help in the prediction of off-target effects. Finally, the database was integrated into a visual interface that enables navigation of the pharmacological space for small molecules. Filtering options were included in order to facilitate and to guide dynamic search of specific queries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.