ArticleThe Journal of biological chemistry2013
Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- The Relationship Between Hypertensive Disorders of Pregnancy and PreLabor Rupture of Membranes in Ethiopia: A Systematic Review and Meta-Analysis of Observational Studies.Health science reports · 2026Review
- The serine protease HtrA regulates Group B Streptococcus virulence and affects the host response to infection.PLoS pathogens · 2025Article
- Extracellular Vesicles Alter Trophoblast Function in Pregnancies Complicated by COVID-19.Journal of extracellular vesicles · 2025Article
- Vasa Previa and the Role of Fetal Fibronectin and Cervical Length Surveillance: A Review.Diagnostics (Basel, Switzerland) · 2024Review
- Stretch Causes cffDNA and HMGB1-Mediated Inflammation and Cellular Stress in Human Fetal Membranes.International journal of molecular sciences · 2024Article
- Heterogeneity of mesenchymal cells in human amniotic membrane at term.Histology and histopathology · 2024Article
- Matrix metalloproteinases in preterm prelabor rupture of membranes in the setting of chorioamnionitis: A scoping review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties.Scientific reports · 2022Article
- The Preventive Effects of Quercetin on Preterm Birth Based on Network Pharmacology and Bioinformatics.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Next generation strategies for preventing preterm birth.Advanced drug delivery reviews · 2021Review
- Tools, techniques, and future opportunities for characterizing the mechanobiology of uterine myometrium.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Targeting Toll-like receptor-4 to tackle preterm birth and fetal inflammatory injury.Clinical & translational immunology · 2020Review
- Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells.Frontiers in physiology · 2020Article
- The Role of Danger Associated Molecular Patterns in Human Fetal Membrane Weakening.Frontiers in physiology · 2020Review
- Role of Toll-Like Receptors in Actuating Stem/Progenitor Cell Repair Mechanisms: Different Functions in Different Cells.Stem cells international · 2019Review
- Mouse models of preterm birth: suggested assessment and reporting guidelines.Biology of reproduction · 2018Review
- Endometrial stromal cell attachment and matrix homeostasis in abdominal wall endometriomas.Human reproduction (Oxford, England) · 2018Observational
- Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes.Scientific reports · 2018Article
- Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain.The Journal of investigative dermatology · 2017Article
- TLR4 Ligands Selectively Synergize to Induce Expression of IL-8.Advances in wound care · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Fetal fibronectin (fFN) in cervical and vaginal secretions has been used as a predictor of preterm delivery. Here, we clarified the pathological function of fFN on cell type-specific matrix metalloproteinases (MMPs) and prostaglandin synthesis in fetal membranes. Treatment of amnion mesenchymal cells with fFN resulted in dramatic increases in MMP-1 and MMP-9 mRNA and enzymatic activity as well as COX-2 mRNA and prostaglandin E(2) synthesis, activating both NFκB and ERK1/2 signaling. Fetal FN-induced increases in MMPs and COX-2 were mediated through its extra domain A and Toll-like receptor 4 expressed in mesenchymal cells. Lipopolysaccharide and TNF-α increased the release of free FN in medium of amnion epithelial cells in culture. Finally, injection of fFN in pregnant mice resulted in preterm birth. Collectively, these results indicate that fFN is not only a marker of preterm delivery but also plays a significant role in the pathogenesis of preterm labor and premature rupture of fetal membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.