ReviewAdvanced healthcare materials2012
Emerging technologies for assembly of microscale hydrogels.
Review in Advanced healthcare materials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02824471 (Sickle Cell Disease), which is not on this map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sickle Cell Disease (SCD) Biochip': Towards a Simple and Reliable Way to Monitor Sickle Cell Disease
Who cites it
35 citing papers in PubMed.
- Cell-embedded microgels as emerging miniature 3D tissue-mimics toward biochip-based toxicity screening.Bioengineering & translational medicine · 2026Review
- Progress in the Application of Organoids-On-A-Chip in Diseases.Organogenesis · 2024Review
- Unveiling the Potential of Single-Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives.Small science · 2024Article
- Hydrogel Microparticles for Bone Regeneration.Gels (Basel, Switzerland) · 2023Review
- The application and prospects of 3D printable microgel in biomedical science and engineering.International journal of bioprinting · 2023Review
- Microgel assembly: Fabrication, characteristics and application in tissue engineering and regenerative medicine.Bioactive materials · 2022Review
- Collagen- and hyaluronic acid-based hydrogels and their biomedical applications.Materials science & engineering. R, Reports : a review journal · 2021Article
- Optimization of the Fluidic-Based Assembly for Three-Dimensional Construction of Multicellular Hydrogel Micro-Architecture in Mimicking Hepatic Lobule-like Tissues.Micromachines · 2021Article
- Reversible Design of Dynamic Assemblies at Small Scales.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2021Article
- Bio-assembling and Bioprinting for Engineering Microvessels from the Bottom Up.International journal of bioprinting · 2021Review
- Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments.Advanced functional materials · 2020Article
- Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel.Scientific reports · 2020Article
- Cell Bioprinting: The 3D-Bioplotter™ Case.Materials (Basel, Switzerland) · 2019Review
- Durable superamphiphobic silica aerogel surfaces for the culture of 3D cellular spheroids.National science review · 2019Article
- Origami-based self-folding of co-cultured NIH/3T3 and HepG2 cells into 3D microstructures.Scientific reports · 2018Article
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
- Spatially and Temporally Controlled Hydrogels for Tissue Engineering.Materials science & engineering. R, Reports : a review journal · 2017Article
- Controlled self-assembly of alginate microgels by rapidly binding molecule pairs.Lab on a chip · 2017Article
- Cooperative Micromanipulation Using the Independent Actuation of Fifty Microrobots in Parallel.Scientific reports · 2017Article
- Surface acoustic waves induced micropatterning of cells in gelatin methacryloyl (GelMA) hydrogels.Biofabrication · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Assembly of cell encapsulating building blocks (i.e., microscale hydrogels) has significant applications in areas including regenerative medicine, tissue engineering, and cell-based in vitro assays for pharmaceutical research and drug discovery. Inspired by the repeating functional units observed in native tissues and biological systems (e.g., the lobule in liver, the nephron in kidney), assembly technologies aim to generate complex tissue structures by organizing microscale building blocks. Novel assembly technologies enable fabrication of engineered tissue constructs with controlled properties including tunable microarchitectural and predefined compositional features. Recent advances in micro- and nano-scale technologies have enabled engineering of microgel based three dimensional (3D) constructs. There is a need for high-throughput and scalable methods to assemble microscale units with a complex 3D micro-architecture. Emerging assembly methods include novel technologies based on microfluidics, acoustic and magnetic fields, nanotextured surfaces, and surface tension. In this review, we survey emerging microscale hydrogel assembly methods offering rapid, scalable microgel assembly in 3D, and provide future perspectives and discuss potential applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.