ArticleAdvanced healthcare materials2013
Mechanically robust, negative-swelling, mussel-inspired tissue adhesives.
Article in Advanced healthcare materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Multiple-layer mesh from electrospinnable amyloid‑like protein and their application in treating oral ulcer.Nature communications · 2026Article
- Multifunctional Catechol-Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries.Advanced healthcare materials · 2026Article
- Tough adhesive bilayer hydrogels.Cell reports. Physical science · 2026Article
- Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects.Biomimetics (Basel, Switzerland) · 2025Review
- Carbonized Polymer Dot-Tannic Acid Nanoglue: Tissue Reinforcement with Concurrent Fluorescent Tracking, Insulin Delivery, and Reactive Oxygen Species Regulation for Normal and Diabetic Wound Healing.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Recent progress in low-swellable polymer-based smart photonic crystal sensors.Smart molecules : open access · 2023Review
- Tailoring the Swelling-Shrinkable Behavior of Hydrogels for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Injectable, stretchable, toughened, bioadhesive composite hydrogel for bladder injury repair.RSC advances · 2023Article
- Adhesive cryogel particles for bridging confined and irregular tissue defects.Military Medical Research · 2023Article
- Bio-inspired adhesive hydrogel for biomedicine-principles and design strategies.Smart medicine · 2022Review
- In vivo Sealing of Fetoscopy-Induced Fetal Membrane Defects by Mussel Glue.Fetal diagnosis and therapy · 2022Article
- Bridging wounds: tissue adhesives' essential mechanisms, synthesis and characterization, bioinspired adhesives and future perspectives.Burns & trauma · 2022Review
- Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications.Angewandte Chemie (International ed. in English) · 2021Article
- Robust Hydrogel Adhesive with Dual Hydrogen Bond Networks.Molecules (Basel, Switzerland) · 2021Article
- Tissue Adhesives: From Research to Clinical Translation.Nano today · 2021Article
- Stable antibacterial polysaccharide-based hydrogels as tissue adhesives for wound healing.RSC advances · 2020Article
- Pressure-Sensitive Tissue Adhesion and Biodegradation of Viscoelastic Polymer Blends.ACS applied materials & interfaces · 2020Article
- Correlating the mass and mechanical property changes during the degradation of PEG-based adhesive.Journal of applied polymer science · 2020Article
- Mussel-inspired bioadhesives in healthcare: design parameters, current trends, and future perspectives.Biomaterials science · 2020Review
- In vivo safety assessment of a bio-inspired bone adhesive.Journal of materials science. Materials in medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Most synthetic polymer hydrogel tissue adhesives and sealants swell considerably in physiologic conditions, which can result in mechanical weakening and adverse medical complications. This paper describes the synthesis and characterization of mechanically tough zero- or negative-swelling mussel-inspired surgical adhesives based on catechol-modified amphiphilic poly(propylene oxide)-poly(ethylene oxide) block copolymers. The formation, swelling, bulk mechanical, and tissue adhesive properties of the resulting thermosensitive gels were characterized. Catechol oxidation at or below room temperature rapidly resulted in a chemically cross-linked network, with subsequent warming to physiological temperature inducing a thermal hydrophobic transition in the PPO domains and providing a mechanism for volumetric reduction and mechanical toughening. The described approach can be easily adapted for other thermally sensitive block copolymers and cross-linking strategies, representing a general approach that can be employed to control swelling and enhance mechanical properties of polymer hydrogels used in a medical context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.