Evidence map›Paper›PMID 23184607›Full record

ArticleMolecular imaging and biology2013

Functionalized magnetonanoparticles in visualization of intracranial tumors on MRI.

Massoud Akhtari, Whitney Pope, Gary Mathern, Rex Moats, Andrew Frew, Mark Mandelkern

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Massoud AkhtariJane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen school of Medicine, University of California, Los Angeles, CA, USA, Akhtarim@ucla.edu
Whitney Pope
Gary Mathern
Rex Moats
Andrew Frew
Mark Mandelkern
University of California, Los Angeles · USUniversity of California System · USSouthern California University for Professional Studies · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood-brain barrier (BBB) and of concentrating in and enhancing the contrast of intracranial tumors on magnetic resonance imaging (MRI). PROCEDURE: Nonradioactive 2-deoxy-D-glucose (2DG) was covalently attached to magnetonanoparticles composed of iron oxide and dextran and prepared for intravenous (tail) injection in the naïve rats and mouse models of glioma. MR images were acquired at 3 and 7 T.

results2DG-MNP increased tumor visibility and improved delineation of tumor margins. Histopathology confirmed that 2DG-MNP crossed the BBB and accumulated within brain parenchyma.

conclusionNonradioactive 2DG-MNP can cross an intact BBB on and improve visualization of tumor and tumor margins on MRI.

Indexed as

Magnetite NanoparticlesAnimalsBrain NeoplasmsCell Line, TumorContrast MediaDeoxyglucoseGliomaHumansMagnetic Resonance ImagingMiceMice, NudeRatsXenograft Model Antitumor AssaysContrast MediaDeoxyglucoseMagnetite Nanoparticles

Identifiers

PMID23184607
OpenAlexW2024654755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.