ArticleAdvanced healthcare materials2013
Self-assembly of cytotoxic peptide amphiphiles into supramolecular membranes for cancer therapy.
Article in Advanced healthcare materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Nano-Engineered Delivery of the Pro-Apoptotic KLA Peptide: Strategies, Synergies, and Future Directions.Biomolecules · 2026Review
- Peptide Electrostatic Modulation Directs Human Neural Cell Fate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Micellization of Lipopeptides Containing Toll-like Receptor Agonist and Integrin Binding Sequences.ACS applied materials & interfaces · 2024Review
- Article
- Recent Advances and Challenges in Nanodelivery Systems for Antimicrobial Peptides (AMPs).Antibiotics (Basel, Switzerland) · 2021Review
- Therapeutic Potential of Novel Mastoparan-Chitosan Nanoconstructs Against Clinical MDRInternational journal of nanomedicine · 2021Article
- Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer.Science advances · 2020Article
- Biomimetic peptide self-assembly for functional materials.Nature reviews. Chemistry · 2020Article
- Self-Assembly of a Catalytically Active Lipopeptide and Its Incorporation into Cubosomes.ACS applied bio materials · 2019Article
- Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges.Frontiers in microbiology · 2018Review
- Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model.Scientific reports · 2017Article
- Smart Nanotransformers with Unique Enzyme-Inducible Structural Changes and Drug Release Properties.Biomacromolecules · 2016Article
- Designed supramolecular filamentous peptides: balance of nanostructure, cytotoxicity and antimicrobial activity.Chemical communications (Cambridge, England) · 2015Article
- Electrostatic control of structure in self-assembled membranes.Small (Weinheim an der Bergstrasse, Germany) · 2014Article
- Supramolecular Nanofibers of Peptide Amphiphiles for Medicine.Israel journal of chemistry · 2013Article
- Self-assembly of biomolecular soft matter.Faraday discussions · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Peptide amphiphiles (PAs) provide a versatile platform for the design of complex and functional material constructs for biomedical applications. The hierarchical self-assembly of PAs with biopolymers is used to create robust hybrid membranes with molecular order on the micron scale. Fabrication of membranes by assembling hyaluronic acid with positively charged PA nanostructures containing anti-cancer PAs bearing a (KLAKLAK)(2) peptide sequence is reported here. Changes in membrane microstructure as the positively charged PA nanostructures vary from cylindrical nanofibers to spherical aggregates are characterized. Results indicate that formation of highly aligned fibrous membranes requires a threshold concentration of nanofibers in solution. Additionally, variation of PA nanostructure morphology from spherical aggregates to cylindrical nanofibers allows membranes to act either as reservoirs for sustained release of cytotoxicity upon enzymatic degradation or as membranes with surface-bound cytotoxicity, respectively. Thus, the self-assembly processes of these PA-biopolymer membranes can be potentially used to design delivery platforms for anti-cancer therapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.