ArticleThe Journal of physiology2013
Interventricular comparison of the energetics of contraction of trabeculae carneae isolated from the rat heart.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Metabolite-sensitive cross-bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics.The Journal of physiology · 2026Article
- Ventricle-Specific Biomechanical Responses to Inotropic and Vasoactive Drugs in Human Myocardial Slices.Journal of cardiovascular translational research · 2026Article
- Cardiac muscle contracts more efficiently at lower contraction frequencies.Experimental physiology · 2025Article
- Sex differences in cardiac energetics in the rat ventricular muscle.Scientific reports · 2024Article
- Isolated cardiac muscle contracting against a real-time model of systemic and pulmonary cardiovascular loads.American journal of physiology. Heart and circulatory physiology · 2023Article
- Article
- Cardiac efficiency and Starling's Law of the Heart.The Journal of physiology · 2022Article
- Work-loop contractions reveal that the afterload-dependent time course of cardiac CaJournal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- An Equivocal Final Link - Quantitative Determination of the Thermodynamic Efficiency of ATP Hydrolysis - Sullies the Chain of Electric, Ionic, Mechanical and Metabolic Steps Underlying Cardiac Contraction.Frontiers in physiology · 2020Article
- Energy expenditure for isometric contractions of right and left ventricular trabeculae over a wide range of frequencies at body temperature.Scientific reports · 2019Article
- Comparison of Biomechanical Properties and Microstructure of Trabeculae Carneae, Papillary Muscles, and Myocardium in the Human Heart.Journal of biomechanical engineering · 2019Article
- Do right-ventricular trabeculae gain energetic advantage from having a greater velocity of shortening?The Journal of physiology · 2017Article
- Experimental and modelling evidence of shortening heat in cardiac muscle.The Journal of physiology · 2017Article
- Does the intercept of the heat-stress relation provide an accurate estimate of cardiac activation heat?The Journal of physiology · 2017Article
- Cardiac tissue structure, properties, and performance: a materials science perspective.Annals of biomedical engineering · 2014Review
- Dietary pre-exposure of rats to fish oil does not enhance myocardial efficiency of isolated working hearts or their left ventricular trabeculae.The Journal of physiology · 2014Article
- Streptozotocin-induced diabetes prolongs twitch duration without affecting the energetics of isolated ventricular trabeculae.Cardiovascular diabetology · 2014Article
- The afterload-dependent peak efficiency of the isolated working rat heart is unaffected by streptozotocin-induced diabetes.Cardiovascular diabetology · 2014Article
- Dietary supplementation with either saturated or unsaturated fatty acids does not affect the mechanoenergetics of the isolated rat heart.Physiological reports · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compare the energetics of right ventricular and left ventricular trabeculae carneae isolated from rat hearts. Using our work-loop calorimeter, we subjected trabeculae to stress-length work (W), designed to mimic the pressure-volume work of the heart. Simultaneous measurement of heat production (Q) allowed calculation of the accompanying change of enthalpy (H = W + Q). From the mechanical measurements (i.e. stress and change of length), we calculated work, shortening velocity and power. In combination with heat measurements, we calculated activation heat (Q(A)), crossbridge heat (Q(xb)) and two measures of cardiac efficiency: 'mechanical efficiency' ((mech) = W/H) and 'crossbridge efficiency' ((xb) = W/(H - Q(A))). With respect to their left ventricular counterparts, right venticular trabeculae have higher peak shortening velocity, and higher peak mechanical efficiency, but with no difference of stress development, twitch duration, work performance, shortening power or crossbridge efficiency. That is, the 35% greater maximum mechanical efficiency of right venticular than left ventricular trabeculae (13.6 vs. 10.2%) is offset by the greater metabolic cost of activation (Q(A)) in the latter. When corrected for this difference, crossbridge efficiency does not differ between the ventricles.
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