ArticleIntensive care medicine2013
Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?
Article in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02461264 (Randomized Multicenter Trial of Two Transfusion Strategies for Patient Receiving Chemotherapy for Acute Leukemia or Hematopoietic Stem Cells With Medico-economic Evaluation of Cost Minimization.), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Multicenter Trial of Two Transfusion Strategies for Patient Receiving Chemotherapy for Acute Leukemia or Hematopoietic Stem Cells With Medico-economic Evaluation of Cost Minimization.
Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Non-invasive assessment of muscle oxygenation may aid in optimising transfusion threshold decisions in ambulatory paediatric patients.Transfusion medicine (Oxford, England) · 2017Trial
- A Simple "Blood-Saving Bundle" Reduces Diagnostic Blood Loss and the Transfusion Rate in Mechanically Ventilated Patients.PloS one · 2015Trial
- Dose-response relationship between transfusion and the incidence of infection in critically ill patients: a systematic review and dose-response meta-analysis.Journal of intensive care · 2025Article
- Is there no such thing as a free lunch? With Patient Blood Management, maybe there is!Blood transfusion = Trasfusione del sangue · 2025Article
- Preoperative consultation for determining the appropriate transfusion strategy.Blood research · 2024Review
- Chronic Critical Illness in Patients With Sepsis is Associated With Persistent Anemia, Inflammation, and Impaired Functional Outcomes.The American surgeon · 2023Article
- Article
- Effects of red blood cell transfusions given to non-septic critically ill patients: a propensity score matched study.Anaesthesiology intensive therapy · 2021Article
- Transfusion, mortality and hemoglobin level: Associations among emergency department patients in Kigali, Rwanda.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2020Article
- Red blood cell transfusion policy: a critical literature review.Blood transfusion = Trasfusione del sangue · 2017Review
- Peri-operative anaemia management in major orthopaedic surgery: the need to find a pathway.Blood transfusion = Trasfusione del sangue · 2017Article
- Appropriate use of red blood cell transfusion in emergency departments: a study in five emergency departments.Blood transfusion = Trasfusione del sangue · 2017Article
- Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness.Transfusion · 2017Review
- Anaemia is not a risk factor for progression of acute kidney injury: a retrospective analysis.Critical care (London, England) · 2016Article
- Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction.PloS one · 2016Article
- Prevention and treatment of sepsis-induced acute kidney injury: an update.Annals of intensive care · 2015Article
- Alleviating central venous oxygen saturation (ScvO2): a new approach of kidney protection after cardiac surgery?Critical care (London, England) · 2015Article
- Pre-operative anaemia: prevalence, consequences and approaches to management.Blood transfusion = Trasfusione del sangue · 2015Review
- Red blood cell transfusion in septic shock - clinical characteristics and outcome of unselected patients in a prospective, multicentre cohort.Scandinavian journal of trauma, resuscitation and emergency medicine · 2014Observational
- Year in review in Intensive Care Medicine 2013: I. Acute kidney injury, ultrasound, hemodynamics, cardiac arrest, transfusion, neurocritical care, and nutrition.Intensive care medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was undertaken to investigate the efficacy of red blood cell transfusion (RBCT) at reversing the deleterious effects of moderate anemia in critically ill, non-bleeding patients.
methodsThis was a retrospective, pair-matched (ratio 1:1) cohort study. Non-bleeding critically ill patients with moderate anemia (nadir hemoglobin level between 70 and 95 g/l), admitted to the ICU over a 27-month period, were included. Anemic patients were included upon meeting five matching criteria of having the same nadir hemoglobin (±5 g/l), APACHE II score (±5), SOFA score (±2), admission diagnostic group, and age (±5 years). Outcome events occurring over the whole ICU stay and after RBCT were collected. After hospital discharge, all patients had a 2-year follow-up period.
resultsTwo hundred fourteen non-transfused anemic patients (NTAPs) were successfully matched with 214 transfused anemic patients (TAPs). In addition to the matching criteria, at baseline, both groups were homogenous with respect to multiple comorbidities. Compared with TAPs, NTAPs showed significantly lower rates of hospital mortality (21 vs.13 %, respectively; p < 0.05) and ICU re-admission (7.4 vs. 1.9 %, respectively; p < 0.05). Additionally, NTAPs had significantly lower rates of nosocomial infection (12.9 vs. 6.7 %, respectively; p < 0.05) and acute kidney injury (24.8 vs. 16.7 %, respectively; p < 0.05). Similar results were obtained in subgroup analysis where only more anemic patients (68 matched pairs) or patients with cardiovascular comorbidities (63 matched pairs) were considered.
conclusionsRBCT does not improve the clinical outcome in non-bleeding critically ill patients with moderate anemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.