Trial reportIntensive care medicine2013
Noninvasive mechanical ventilation in patients having declined tracheal intubation.
Trial report in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Qualitative Outcomes After Palliative Noninvasive Mechanical Ventilation : OVNI Study
Treatment of Dyspnea in Do-not-intubate (DNI) Patients
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Do-not-intubate orders in patients with acute respiratory failure: a systematic review and meta-analysis.Intensive care medicine · 2020Pooled it
- Palliative care in the ICU: relief of pain, dyspnea, and thirst--a report from the IPAL-ICU Advisory Board.Intensive care medicine · 2014Guideline
- Trial
- Changing use of noninvasive ventilation in critically ill patients: trends over 15 years in francophone countries.Intensive care medicine · 2016Trial
- The effects of a 2-h trial of high-flow oxygen by nasal cannula versus Venturi mask in immunocompromised patients with hypoxemic acute respiratory failure: a multicenter randomized trial.Critical care (London, England) · 2015Trial
- Anxiety, depression and distress in family members of people who have experienced a critical care admission: a systematic review and Bayesian meta-analysis.Journal of intensive care · 2025Article
- Observational
- Oxygen therapy and noninvasive respiratory supports in acute hypoxemic respiratory failure: a narrative review.Annals of intensive care · 2024Review
- Prediction of post-traumatic stress disorder in family members of ICU patients: a machine learning approach.Intensive care medicine · 2024Article
- Factors Associated with and Prognosis Impact of Perceived Sleep Quality and Estimated Quantity in Patients Receiving Non-Invasive Ventilation for Acute Respiratory Failure.Journal of clinical medicine · 2022Article
- Prognostic factors for advanced lung cancer patients with do-not-intubate order in intensive care unit: a retrospective study.BMC pulmonary medicine · 2022Article
- Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals.Critical care (London, England) · 2021Article
- Palliative, palliative or palliative?Critical care (London, England) · 2021Article
- Observational
- Trends in Noninvasive and Invasive Mechanical Ventilation Among Medicare Beneficiaries at the End of Life.JAMA internal medicine · 2021Article
- How to ventilate obstructive and asthmatic patients.Intensive care medicine · 2020Review
- Continuous positive airway pressure to avoid intubation in SARS-CoV-2 pneumonia: a two-period retrospective case-control study.The European respiratory journal · 2020Article
- Post traumatic stress symptoms, anxiety, and depression in patients after intensive care unit discharge - a longitudinal cohort study from a LMIC tertiary care centre.BMC psychiatry · 2020Article
- Ventilator Support and Oxygen Therapy in Palliative and End-of-Life Care in the Elderly.Turkish thoracic journal · 2020Review
- Comparison of NIV-NAVA and NCPAP in facilitating extubation for very preterm infants.BMC pediatrics · 2019Article
Corrections and comments
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Authors and funding
33 authors at 20 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNoninvasive ventilation (NIV) is a treatment option in patients with acute respiratory failure who are good candidates for intensive care but have declined tracheal intubation. The aim of our study was to report outcomes after NIV in patients with a do-not-intubate (DNI) order.
methodsProspective observational cohort study in all patients who received NIV for acute respiratory failure in 54 ICUs in France and Belgium, in 2010/2011.
resultsGoals of care, comfort, and vital status were assessed daily. On day 90, a telephone interview with patients and relatives recorded health-related quality of life (HRQOL), posttraumatic stress disorder-related symptoms, and symptoms of anxiety and depression. Post-ICU burden was compared between DNI patients and patients receiving NIV with no treatment-limitation decisions (TLD). Of 780 NIV patients, 574 received NIV with no TLD, and 134 had DNI orders. Hospital mortality was 44 % in DNI patients and 12 % in the no-TLD group. Mortality in the DNI group was lowest in COPD patients compared to other patients in the DNI group (34 vs. 51 %, P = 0.01). In the DNI group, HRQOL showed no significant decline on day 90 compared to baseline; day-90 data of patients and relatives did not differ from those in the no-TLD group.
conclusionsDo-not-intubate status was present among one-fifth of ICU patients who received NIV. DNI patients who were alive on day 90 experienced no decrease in HRQOL compared to baseline. The prevalences of anxiety, depression, and PTSD-related symptoms in these patients and their relatives were similar to those seen after NIV was used as part of full-code management (clinicaltrial.govNCT01449331).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.