ArticleDiabetologia2013
Serum potassium is associated with prediabetes and newly diagnosed diabetes in hypertensive adults from the general population: the KORA F4-study.
Article in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA).PloS one · 2016Trial
- Serum sodium level is inversely associated with new-onset diabetes in hypertensive patients.Journal of diabetes · 2022Article
- New clusters of serum electrolytes aid in stratification of diabetes and metabolic risk.Journal of diabetes · 2022Article
- Ageing Investigation Using Two-Time-Point Metabolomics Data from KORA and CARLA Studies.Metabolites · 2019Article
- Article
- Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test.Frontiers in endocrinology · 2018Article
- A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population.Journal of the American Society of Nephrology : JASN · 2016Article
- The role of dietary potassium in hypertension and diabetes.Journal of physiology and biochemistry · 2016Review
- Identification of Risk Factors Affecting Impaired Fasting Glucose and Diabetes in Adult Patients from Northeast China.International journal of environmental research and public health · 2015Article
- Tolerability of Antihypertensive Medications in Older Adults.Drugs & aging · 2015Review
- Potassium and glucose measures in older adults: the Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Serum potassium and glucose regulation in the ADDITION-Leicester screening study.Journal of diabetes research · 2015Article
- Impact of chronic diuretic treatment on glucose homeostasis.Diabetology & metabolic syndrome · 2013Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisEvidence suggests that low serum potassium concentrations or hypokalaemia induced by the intake of diuretics are associated with incident diabetes and increased risk for diabetes in persons with hypertension. We examined a possible association between serum potassium and prediabetes (defined as isolated impaired fasting glucose [i-IFG], isolated impaired glucose tolerance [i-IGT] or combined IFG/IGT), as well as known and newly diagnosed diabetes (NDD), in 32- to 81-year-old men and women with and without hypertension.
methodsThis cross-sectional analysis was based on 2,948 participants in the Cooperative Health Research in the Region of Augsburg (KORA) F4 study conducted in 2006-2008 in southern Germany. Serum concentrations of potassium were measured by indirect potentiometry.
resultsIn the total sample there was no association between serum potassium concentrations and prediabetes. In hypertensive persons however serum potassium levels in the first and second quartile compared with the highest quartile were independently significantly associated with prediabetes after multivariable adjustment (OR for prediabetes, 2.02 [95% CI 1.27, 3.21] for quartile 2 and 2.00 [95% CI 1.27, 3.15] for quartile 1), while in persons without hypertension no association was found. In multinomial logistic regression analysis these findings could be confirmed. In hypertensive participants after multivariable adjustment the associations were statistically significant for i-IGT and NDD (i-IGT OR 1.23; NDD OR 1.41). However, in non-hypertensive persons, all associations between serum potassium levels and each of the categories of impaired glucose regulation were non-significant. CONCLUSIONS/
interpretationSerum potassium levels were independently associated with prediabetes and NDD in hypertensive adults from the general population.
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