ArticleGenetics2013
Genomic background and generation time influence deleterious mutation rates in Daphnia.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Developmental speed and chronological time exert opposing effects on the spontaneous mutation rate inEvolution letters · 2026Article
- Microsatellite Variation of African ElephantsEcology and evolution · 2025Article
- Evolutionary Insights from a Large-Scale Survey of Population-Genomic Variation.Molecular biology and evolution · 2023Article
- Identification of a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1.Nature communications · 2023Article
- Evolutionary Insights from a Large-scale Survey of Population-genomic Variation.bioRxiv : the preprint server for biology · 2023Article
- Fitness effects of spontaneous mutations in a warming world.Evolution; international journal of organic evolution · 2021Article
- High and Highly Variable Spontaneous Mutation Rates in Daphnia.Molecular biology and evolution · 2020Article
- Fitness and Genomic Consequences of Chronic Exposure to Low Levels of Copper and Nickel inG3 (Bethesda, Md.) · 2019Article
- Evolved tolerance to freshwater salinization in zooplankton: life-history trade-offs, cross-tolerance and reducing cascading effects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Hierarchical Assessment of Mutation Properties inG3 (Bethesda, Md.) · 2018Article
- Reproductive Longevity Predicts Mutation Rates in Primates.Current biology : CB · 2018Article
- Patterns of Substitution Rate Variation at Many Nuclear Loci in Two Species Trios in the Brassicaceae Partitioned with ANOVA.Journal of molecular evolution · 2016Article
- Gene Expression Evolves under a House-of-Cards Model of Stabilizing Selection.Molecular biology and evolution · 2015Article
- Population-genomic insights into the evolutionary origin and fate of obligately asexual Daphnia pulex.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The effect of spontaneous mutations on competitive ability.Journal of evolutionary biology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Understanding how genetic variation is generated and how selection shapes mutation rates over evolutionary time requires knowledge of the factors influencing mutation and its effects on quantitative traits. We explore the impact of two factors, genomic background and generation time, on deleterious mutation in Daphnia pulicaria, a cyclically parthenogenic aquatic microcrustacean, using parallel mutation-accumulation experiments. The deleterious mutational properties of life-history characters for individuals from two different populations, and for individuals maintained at two different generation times, were quantified and compared. Mutational properties varied between populations, especially for clutch size, suggesting that genomic background influences mutational properties for some characters. Generation time was found to have a greater effect on mutational properties, with higher per-generation deleterious mutation rates in lines with longer generation times. These results suggest that differences in genetic architecture among populations and species may be explained in part by demographic features that significantly influence generation time and therefore the rate of mutation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.