ArticleAntimicrobial agents and chemotherapy2013
Neisseria gonorrhoeae strain with high-level resistance to spectinomycin due to a novel resistance mechanism (mutated ribosomal protein S5) verified in Norway.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 78 citations in OpenAlex.
- Evidence for a Constrained Mutational Pathway to High-Level Spectinomycin Resistance inInternational journal of molecular sciences · 2026Article
- The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.The Journal of antimicrobial chemotherapy · 2024Article
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- Biochemical Atypia in RussianMicroorganisms · 2022Article
- Molecular Mechanisms of Drug Resistance and Epidemiology of Multidrug-Resistant Variants ofInternational journal of molecular sciences · 2022Review
- Improved management can be achieved by introducing additional parameters in the syndromic diagnosis of nonviral sexually transmitted infections at low-resource settings.AJOG global reports · 2022Article
- Spectinomycin resistance inFrontiers in microbiology · 2022Article
- High-Resolution Melting Analysis to Detect Antimicrobial Resistance Determinants in South AfricanInternational journal of microbiology · 2022Article
- Genotoxic Agents Produce Stressor-Specific Spectra of Spectinomycin Resistance Mutations Based on Mechanism of Action and Selection in Bacillus subtilis.Antimicrobial agents and chemotherapy · 2021Article
- Typing ofAntimicrobial agents and chemotherapy · 2021Article
- A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch.Genome medicine · 2021Article
- Characterizing the portability of phage-encoded homologous recombination proteins.Nature chemical biology · 2021Article
- Neisseria gonorrhoeae Antimicrobial Resistance: Past to Present to Future.Current microbiology · 2021Review
- Recent advances in understanding and combattingFaculty reviews · 2021Review
- Multiresistant Neisseria gonorrhoeae: a new threat in second decade of the XXI century.Medical microbiology and immunology · 2020Review
- Genomic epidemiology and population structure ofMicrobial genomics · 2020Article
- Gonococcal urethritis caused by a multidrug resistantEmerging microbes & infections · 2020Article
- ShanghaiFrontiers in microbiology · 2020Article
- Evaluation of apramycin against spectinomycin-resistant and -susceptible strains of Neisseria gonorrhoeae.The Journal of antimicrobial chemotherapy · 2019Article
- Applications of genomics to slow the spread of multidrug-resistant Neisseria gonorrhoeae.Annals of the New York Academy of Sciences · 2019Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gonorrhea may become untreatable, and new treatment options are essential. Verified resistance to spectinomycin is exceedingly rare. However, we describe a high-level spectinomycin-resistant (MIC, >1,024 μg/ml) Neisseria gonorrhoeae strain from Norway with a novel resistance mechanism. The resistance determinant was a deletion of codon 27 (valine) and a K28E alteration in the ribosomal protein 5S. The traditional spectinomycin resistance gene (16S rRNA) was wild type. Despite this exceedingly rare finding, spectinomycin available for treatment of ceftriaxone-resistant urogenital gonorrhea would be very valuable.
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